| Inhibition of Na(+)/H(+) exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury. | |
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MedLine Citation:
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PMID: 11549379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Na(+)/H(+) exchanger (NHE) is activated during ischemia-reperfusion in an effort to restore intracellular pH to normal levels. Inhibition of NHE with non-selective amiloride derivatives has been shown to be neuroprotective and to attenuate free fatty acid efflux during ischemia-reperfusion. We evaluated the effects of SM-20220 (20 microM), a highly selective and specific NHE inhibitor, applied topically onto rat cerebral cortex prior to and during a 20-min period of ischemia. SM-20220 application significantly reduced the ischemia-evoked efflux of myristic, palmitic, and arachidonic acids during both ischemia and reperfusion with significant decreases in linoleic and docosahexaenoic levels during reperfusion. This study confirms the importance of NHEs in eliciting free fatty acid efflux, inhibition of which may be an essential component of the neuroprotective benefits of NHE inhibitors in ischemia-reperfusion injury. |
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Authors:
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J G Pilitsis; F G Diaz; M H O'Regan; J W Phillis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 913 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-10 Completed Date: 2001-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 156-8 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Wayne State University, UHC-6E, 4201 St. Antoine, Detroit, MI 48201, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
/
drug therapy,
metabolism*,
physiopathology Amides / pharmacology* Animals Brain Ischemia / drug therapy, enzymology*, physiopathology Cell Membrane / drug effects, enzymology Cerebral Cortex / drug effects, enzymology*, physiopathology Down-Regulation / drug effects, physiology Fatty Acids, Nonesterified / metabolism* Indoles / pharmacology* Intracellular Fluid / drug effects, enzymology Ion Transport / drug effects, physiology Neuroprotective Agents / pharmacology Phospholipases / drug effects, metabolism Rats Reperfusion Injury / drug therapy, enzymology*, physiopathology Sodium / metabolism Sodium-Hydrogen Antiporter / drug effects, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Fatty Acids, Nonesterified; 0/Indoles; 0/Neuroprotective Agents; 0/SM 20220; 0/Sodium-Hydrogen Antiporter; 7440-23-5/Sodium; EC 3.1.-/Phospholipases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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