Document Detail

Inhibition of Na(+)/H(+) exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury.
MedLine Citation:
PMID:  11549379     Owner:  NLM     Status:  MEDLINE    
The Na(+)/H(+) exchanger (NHE) is activated during ischemia-reperfusion in an effort to restore intracellular pH to normal levels. Inhibition of NHE with non-selective amiloride derivatives has been shown to be neuroprotective and to attenuate free fatty acid efflux during ischemia-reperfusion. We evaluated the effects of SM-20220 (20 microM), a highly selective and specific NHE inhibitor, applied topically onto rat cerebral cortex prior to and during a 20-min period of ischemia. SM-20220 application significantly reduced the ischemia-evoked efflux of myristic, palmitic, and arachidonic acids during both ischemia and reperfusion with significant decreases in linoleic and docosahexaenoic levels during reperfusion. This study confirms the importance of NHEs in eliciting free fatty acid efflux, inhibition of which may be an essential component of the neuroprotective benefits of NHE inhibitors in ischemia-reperfusion injury.
J G Pilitsis; F G Diaz; M H O'Regan; J W Phillis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  913     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-10     Completed Date:  2001-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  156-8     Citation Subset:  IM    
Department of Neurosurgery, Wayne State University, UHC-6E, 4201 St. Antoine, Detroit, MI 48201, USA.
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MeSH Terms
Acidosis / drug therapy,  metabolism*,  physiopathology
Amides / pharmacology*
Brain Ischemia / drug therapy,  enzymology*,  physiopathology
Cell Membrane / drug effects,  enzymology
Cerebral Cortex / drug effects,  enzymology*,  physiopathology
Down-Regulation / drug effects,  physiology
Fatty Acids, Nonesterified / metabolism*
Indoles / pharmacology*
Intracellular Fluid / drug effects,  enzymology
Ion Transport / drug effects,  physiology
Neuroprotective Agents / pharmacology
Phospholipases / drug effects,  metabolism
Reperfusion Injury / drug therapy,  enzymology*,  physiopathology
Sodium / metabolism
Sodium-Hydrogen Antiporter / drug effects,  metabolism*
Reg. No./Substance:
0/Amides; 0/Fatty Acids, Nonesterified; 0/Indoles; 0/Neuroprotective Agents; 0/SM 20220; 0/Sodium-Hydrogen Antiporter; 7440-23-5/Sodium; EC 3.1.-/Phospholipases

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