Document Detail

Inhibition of erythrocyte Na,K-ATPase activity during anticipatory hypoventilation in micropigs.
MedLine Citation:
PMID:  8931839     Owner:  NLM     Status:  MEDLINE    
Previous studies with micropigs showed that conditioned suppression of respiration preceding the onset of an avoidance task was associated with increased pCO2, decreased plasma pH, decreased hematocrit, and increased blood pressure with no change in heart rate. Voluntary hypoventilation by humans, which evoked similar effects, was found to elicit increases in plasma endogenous digitalis-like factors (EDLF) and decreases in erythrocyte Na,K-ATPase. The present study investigated plasma EDLF and Na,K-ATPase activity in micropigs preceding and during avoidance sessions. Compared with levels in a controlled environment, 1 h of quiet waiting for the onset of a 30-min avoidance task was associated with hypoventilation, acidification of the plasma, and a decrease in hematocrit with progressive increases in plasma EDLF, and decreased in erythrocyte Na,K-ATPase activity (1.67 +/- 0.35 v 2.73 +/- 0.24 mumol Pi/mL er/h). Systolic blood pressure increased (126.5 +/- 5.7 v 121.7 +/- 4.2 mm Hg) during preavoidance periods, with no changes in heart rate (89.5 +/- 3.9 v 89.4 +/- 4.0 beats/min). During the avoidance sessions, plasma EDLF, systolic blood pressure (126.7 +/- 4.5 mm Hg), and heart rate (107.3 +/- 4.8 beats/min) were elevated above the first 10 min of preavoidance, whereas Na,K-ATPase activity returned toward control values (2.46 +/- 0.83 mumol Pi/mL er/h). These findings are consistent with the view that elevation of blood pressure during behaviorally induced hypoventilation in micropigs is mediated in part by inhibition of Na,K-ATPase by increases in plasma EDLF due to expanded plasma volume.
O V Fedorova; A W French; D E Anderson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  9     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-18     Completed Date:  1997-02-18     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1126-31     Citation Subset:  IM    
Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA.
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MeSH Terms
Avoidance Learning
Bicarbonates / blood
Blood Pressure
Erythrocytes / enzymology*
Heart Rate
Hydrocortisone / blood
Hydrogen-Ion Concentration
Hypoventilation / blood,  enzymology*
Oxygen / blood
Potassium / blood
Saponins / metabolism*
Sodium / blood
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*
Swine, Miniature
Reg. No./Substance:
0/Bicarbonates; 0/Cardenolides; 0/Saponins; 0/digoxin-like factors; 20830-75-5/Digoxin; 50-23-7/Hydrocortisone; 7440-09-7/Potassium; 7440-23-5/Sodium; 7782-44-7/Oxygen; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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