Document Detail


Inhibition of eosinophil migration by lactoferrin.
MedLine Citation:
PMID:  19918259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eosinophilic granulocytes are innate effector cells that are important in immune responses against helminth parasitic infections and contribute towards the pathology associated with allergic inflammatory conditions, including allergic rhinitis and asthma. Their recruitment to inflammatory sites occurs in response to chemotactic and activation signals, such as eotaxin and interleukin-5, and is a tightly controlled process. However, the mechanisms that counterbalance these positive chemoattractive processes, thereby preventing excessive eosinophil infiltration, have received little attention. Here, we show that, lactoferrin (LTF), a pleiotropic 80-kDa glycoprotein with iron-binding properties, acts as a powerful inhibitor of eosinophil migration. Irrespective of its source (milk or neutrophil derived), LTF inhibits eotaxin-stimulated eosinophil migration with no effects on eosinophil viability. Transferrin, a closely related cationic glycoprotein, failed to produce an analogous effect. Furthermore, the iron-saturation status of LTF did not influence the observed inhibitory effect on migration, proving that LTF exerts its effect on eosinophil chemotaxis independent of its iron-chelating activity. These results highlight LTF as one of the few molecules reported to negatively regulate eosinophil migration. Thus, through its ability to inhibit eosinophil migration, LTF has potential as an effective therapeutic in the control of eosinophil infiltration in atopic inflammatory conditions.
Authors:
Irini Bournazou; Karen J Mackenzie; Rodger Duffin; Adriano G Rossi; Christopher D Gregory
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-17
Journal Detail:
Title:  Immunology and cell biology     Volume:  88     ISSN:  1440-1711     ISO Abbreviation:  Immunol. Cell Biol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-18     Completed Date:  2010-05-18     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8706300     Medline TA:  Immunol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chemokine CCL11 / pharmacology
Chemotaxis, Leukocyte / drug effects*
Eosinophils / cytology*,  drug effects*
Humans
Iron / metabolism
Lactoferrin / metabolism,  pharmacology*
Protein Binding / drug effects
Grant Support
ID/Acronym/Agency:
G0601481//Medical Research Council; G0701350//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
0/Chemokine CCL11; E1UOL152H7/Iron; EC 3.4.21.-/Lactoferrin

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