Document Detail

Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, gallic acid and caffeine.
MedLine Citation:
PMID:  10478825     Owner:  NLM     Status:  MEDLINE    
The antimutagenic properties of various tea extracts (green tea, pauchong tea, oolong tea and black tea) and their components including (-)-epigallocatechin-3-gallate (EGCG), gallic acid and caffeine were examined by the Ames test. The antimutagenic activity of the green tea extract against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), folpet and monocrotophos was greater than those of pouchong, oolong and black tea extracts. The antimutagenic effects of tea extracts against 2-acetylaminofluorene (AAF) decreased as follows: oolong tea > pauchong tea > black tea > green tea. Furthermore, black tea showed a greater antimutagenic activity against benzo[a]pyrene (BP). The pauchong tea showed a stronger inhibitory effect against 9-aminoacridine (9AA) and aflatoxin B1 (AFB1) than other tea extracts. EGCG markedly suppressed the direct-acting mutagenicity of MNNG, N-nitroso-N-methylurea (MNU), captan, and folpet which were alkylating agents and fungicides. Similarly, gallic acid, the major component of black tea strongly inhibited the mutagenicity of 9AA, and moderately inhibited the mutagenicity of MNNG and folpet. The caffeine was less active. EGCG and gallic acid perhaps could act as nucleophiles to scavenge the electrophilic mutagens. Taken together, these results suggest that formation of different metabolites during various stages of tea fermentation may affect antimutagenic potencies against different types of chemical mutagens.
T C Hour; Y C Liang; I S Chu; J K Lin
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  37     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-09-09     Completed Date:  1999-09-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  569-79     Citation Subset:  IM    
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei.
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MeSH Terms
Antimutagenic Agents / pharmacology*
Caffeine / pharmacology*
Catechin / analogs & derivatives*,  pharmacology
Drug Interactions
Gallic Acid / pharmacology*
Mutagenicity Tests
Plant Extracts / pharmacology
Rats, Sprague-Dawley
Salmonella typhimurium / drug effects
Tea / chemistry*
Reg. No./Substance:
0/Antimutagenic Agents; 0/Plant Extracts; 0/Tea; 149-91-7/Gallic Acid; 154-23-4/Catechin; 58-08-2/Caffeine; 989-51-5/epigallocatechin gallate

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