| Inhibition of the effects of angiotensin II on adrenal steroid production by dietary sodium. | |
| | |
MedLine Citation:
|
PMID: 4310514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The pressor octapeptide, angiotensin II, can stimulate the production of aldosterone by the adrenal cortex. The present results show that in the dog a high-sodium diet can eliminate the steroidogenic action of angiotensin II, which is thus dissociated from the pressor action which remains. Angiotensin II was infused intravenously for 48 hours into conscious, undisturbed hypophysectomized dogs that were receiving each day either 60 or 200 mEq of dietary sodium. Blood pressure and secretion of aldosterone, corticosterone, and cortisol were measured (1) throughout the infusion in some dogs, and (2) at the end of the infusion in all dogs. In those dogs receiving 60 mEq of sodium, angiotensin II elevated the blood pressure and produced sustained increases of secretion of aldosterone, corticosterone, and cortisol. In those dogs receiving 200 mEq of sodium, angiotensin II, while retaining its pressor activity, had no effect on the production of aldosterone, corticosterone, or cortisol after 24 hours. Thus, if angiotensin II can produce hypertension clinically, there need not be secondary aldosteronism as well. |
| | |
Authors:
|
W W Davis; L R Burwell; F C Bartter |
Related Documents
:
|
18935724 - The blood pressure variability, arterial elasticity and humoral factors in subjects wit... 9426094 - Haemodynamic and endocrinological effects of noninvasive mechanical ventilation in resp... 15830034 - Renal and humoral pathophysiological actions of angiotensin ii in congestive heart fail... 2442774 - Autometrically and automatically monitored, iatrogenous, inhalant-decongestant-associat... 11153184 - Critical care nurses' knowledge of arterial pressure monitoring. 8594914 - Filling characteristics of left ventricle in newborn lambs. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 63 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1969 Jul |
Date Detail:
|
Created Date: 1969-12-16 Completed Date: 1969-12-16 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 718-23 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Hormones
/
secretion* Aldosterone / secretion Angiotensin II / antagonists & inhibitors* Animals Blood Pressure / drug effects* Corticosterone / secretion Diet Dogs Hydrocortisone / secretion Hypophysectomy Sodium / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 11128-99-7/Angiotensin II; 50-22-6/Corticosterone; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 7440-23-5/Sodium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bovine splenic nerve: characterization of noradrenaline-containing vesicles and other cell organelle...
Next Document: Genetic control by the hr-locus of susceptibility and resistance to leukemia.