| Inhibition of early preneoplastic events in the rat liver by the somatostatin analog lanreotide. | |
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MedLine Citation:
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PMID: 17900309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death, and its incidence is increasing worldwide. Due to the known risk factors (mainly hepatitis B and C viruses), we believe there is a rationale for a chemopreventive approach to treat HCC. Here, based on described in vitro data, we evaluated the preventive effects of lanreotide, a somatostatin analog, on the induction of early carcinogenic events. We monitored preneoplastic foci induced by a two-stage initiation/promotion model of hepatocarcinogenesis in male Wistar rats, using diethylnitrosamine and 2-acetylaminofluorene. Lanreotide was given starting the day after the first diethylnitrosamine injection. By quantitative morphometry, we showed that lanreotide significantly decreases the size of induced preneoplastic foci. Analysis of proliferation and apoptosis assessed by immunohistochemistry, showed decreased proliferation and increased cell death in rats treated with lanreotide. As these events were associated with a significant decreased expression of the cell cycle regulator cyclin D1 and an increased expression of the cyclin-dependent kinase inhibitor p27(kip1) compared to the non-treated group, it is tempting to speculate that these factors are involved in the favorable effect of lanreotide. In conclusion, lanreotide significantly decreases early carcinogenic transformation in a two-step rat model. As lanreotide has a low toxicity profile, we believe it would be interesting to evaluate its effect in chemoprevention of HCC. |
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Authors:
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Ivan Borbath; Isabelle A Leclercq; Jorge Abarca-Quinones; Christine Desaeger; Valérie Lebrun; Pierre Moulin; Christine Sempoux; Yves Horsmans |
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Publication Detail:
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Type: Journal Article Date: 2007-09-27 |
Journal Detail:
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Title: Cancer science Volume: 98 ISSN: 1349-7006 ISO Abbreviation: Cancer Sci. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-10-25 Completed Date: 2007-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168776 Medline TA: Cancer Sci Country: England |
Other Details:
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Languages: eng Pagination: 1831-9 Citation Subset: IM |
Affiliation:
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Gastroenterology Laboratory, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Avenue Hippocrate, 10, Brussels 1200, Belgium. ivan.borbath@clin.ucl.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / therapeutic use* Carcinoma, Hepatocellular / chemically induced, pathology, prevention & control* Cell Division Diethylnitrosamine / toxicity Liver Neoplasms / chemically induced, pathology, prevention & control* Male Peptides, Cyclic / therapeutic use* Polymerase Chain Reaction Precancerous Conditions / pathology, prevention & control* RNA, Neoplasm / genetics, isolation & purification Rats Rats, Wistar Somatostatin / analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Peptides, Cyclic; 0/RNA, Neoplasm; 118992-92-0/lanreotide; 51110-01-1/Somatostatin; 55-18-5/Diethylnitrosamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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