Document Detail


Inhibition of the dorsal premotor cortex does not repair surround inhibition in writer's cramp patients.
MedLine Citation:
PMID:  23192337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Writer's cramp is a task-specific form of focal dystonia, characterized by abnormal movements and postures of the hand and arm during writing. Two consistent abnormalities in its pathophysiology are a loss of surround inhibition and overactivity of the dorsal premotor cortex (PMd). This study aimed to assess a possible link between these two phenomena by investigating whether PMd inhibition leads to an improvement of surround inhibition, in parallel with previously demonstrated writing improvement. Fifteen writer's cramp patients and ten controls performed a simple motor hand task during which surround inhibition was measured using transcranial magnetic stimulation. Motor cortical excitability was measured of the active and surround muscles at three phases of the task. Surround inhibition and writing performance were assessed before and after PMd inhibitory continuous theta burst stimulation. In contrast to healthy controls, patients did not show inhibition of the abductor digiti minimi muscle during movement initiation of the first dorsal interosseus muscle, confirming the loss of surround inhibition. PMd inhibition led to an improvement of writing speed in writer's cramp patients. However, in both groups, no changes in surround inhibition were observed. The results confirm a role for the PMd in the pathophysiology of writer's cramp. We show that PMd inhibition does not lead to restoration of the surround inhibition defect in writer's cramp, despite the improvement in writing. This questions the involvement of the PMd in the loss of surround inhibition, and perhaps also the direct link between surround inhibition and dystonia.
Authors:
Lidwien C Veugen; Britt S Hoffland; Dick F Stegeman; Bart P van de Warrenburg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-29
Journal Detail:
Title:  Experimental brain research     Volume:  225     ISSN:  1432-1106     ISO Abbreviation:  Exp Brain Res     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-11     Completed Date:  2013-07-22     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Data Interpretation, Statistical
Dystonic Disorders / physiopathology,  rehabilitation*
Electromyography
Female
Handwriting
Humans
Male
Middle Aged
Motor Cortex / physiology*
Psychomotor Performance / physiology
Transcranial Magnetic Stimulation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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