| Inhibition of dopamine-stimulated adenylate cyclase activity by phenoxybenzamine. | |
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MedLine Citation:
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PMID: 729635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phenoxybenzamine at a concentration of 2 X 10(-6 M) produced half-maximal inhibition of dopamine-stimulated adenylate cyclase activity in homogenates of rat striatum. Inhibition was sharply dependent on time and temperature of preincubation with the inhibitor. When included in the preincubation medium, dopamine was nearly 8 times more effective than norepinephrine at protecting against this inhibition, whereas neither isoproterenol nor methoxamine appeared to protect at all. These results suggest a direct, and possibly irreversible, interaction of phenoxybenzamine with the dopamine-binding component of the adenylate cyclase. |
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Authors:
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K G Walton; P Liepmann; R J Baldessarini |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 52 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1978 Nov |
Date Detail:
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Created Date: 1979-03-13 Completed Date: 1979-03-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 231-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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antagonists & inhibitors* Animals Corpus Striatum / enzymology Dopamine / pharmacology* Dopamine Antagonists* Male Phenoxybenzamine / pharmacology* Rats Temperature Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Antagonists; 59-96-1/Phenoxybenzamine; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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