Document Detail


Inhibition of the development of Q-bands on human chromosomes by netropsin.
MedLine Citation:
PMID:  598839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Netropsin, an oligopeptide-type basic antibiotic, having exclusively A-T-specific DNA-binding affinity and situating itself into the minor groove of the double helix, represses the development of Q-bands if human chromosome preparations are treated with it before quinacrine mustard staining. The most probable interpretation of this effect is that netropsin interferes with the intercalation of the dye molecules. It is assumed this phenomenon supports the hypothesis that quinacrine mustard binds preferentially to A-T-rich sequences of DNA in the metaphase chromosomes.
Authors:
J Schlammadinger; H Poulsen; M Mikkelsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  39     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-03-10     Completed Date:  1978-03-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  309-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine
Binding Sites
Chromosomes, Human / drug effects*
DNA
Guanidines / pharmacology*
Humans
Netropsin / pharmacology*
Quinacrine Mustard
Thymine
Chemical
Reg. No./Substance:
0/Guanidines; 1438-30-8/Netropsin; 4213-45-0/Quinacrine Mustard; 58-61-7/Adenosine; 65-71-4/Thymine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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