| Inhibition of delayed hypersensitivity reactions by a new agent, cis-1-methyl-4-isohexylcyclohexane carboxylic acid (IG-10). | |
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MedLine Citation:
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PMID: 2860077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A newly synthesized compound, cis-1-methyl-4-isohexylcyclohexane carboxylic acid (IG-10), has been reported as an inhibitor of delayed hypersensitivity reaction. In the present paper, the mechanisms regarding the inhibitory action of IG-10 was investigated on delayed hypersensitivity reactions. p-Phenylenediamine-induced contact dermatitis in guinea pigs was significantly inhibited when the drug was given in a dose of 100 mg/kg p.o. at various times after challenge with the antigen. IG-10 inhibited both contact dermatitis and monocytes or neutrophils infiltrations induced by picryl chloride in mice. A skin reaction, similar to that seen in the case of delayed hypersensitivity reaction, was induced by an intradermal injection of phytohemagglutinin-P (PHA-P) stimulated lymphocytes in guinea pigs. This reaction was a useful method for assessing the effect of drugs on the release of lymphokines, particularly skin reactive factor (SRF). IG-10 in a concentration of 10(-5) g/ml inhibited the release of SRF as well as the release of migration inhibitory factor (MIF) from guinea pig lymphocytes stimulated by PHA-P. The reduction of delta 4-3-ketone of aldosterone and/or hydrocortisone by rat liver homogenates was not affected with IG-10, unlike that seen in the case of glycyrrhizin. |
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Authors:
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A Koda; I Nakatomi; K Nakamura; H Inoue; T Kamimura |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: International journal of immunopharmacology Volume: 7 ISSN: 0192-0561 ISO Abbreviation: Int. J. Immunopharmacol. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-07-02 Completed Date: 1985-07-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7904799 Medline TA: Int J Immunopharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 41-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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metabolism Animals Cyclohexanecarboxylic Acids / pharmacology* Dermatitis, Contact / prevention & control Erythema / chemically induced Guinea Pigs Histamine H1 Antagonists / pharmacology* Hydrocortisone / metabolism Hypersensitivity, Delayed / prevention & control* Liver / metabolism Lymphocyte Activation Lymphokines / secretion Macrophage Migration-Inhibitory Factors / secretion Male Mice |
| Chemical | |
Reg. No./Substance:
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0/Cyclohexanecarboxylic Acids; 0/Histamine H1 Antagonists; 0/Lymphokines; 0/Macrophage Migration-Inhibitory Factors; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 72788-52-4/IG 10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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