Document Detail

Inhibition of cytotoxic T lymphocyte-mediated lysis by ETYA: effect independent of arachidonic acid metabolism.
MedLine Citation:
PMID:  2981259     Owner:  NLM     Status:  MEDLINE    
Cytotoxic T lymphocyte (CTL)-mediated lysis of target cells was inhibited by 5,8,11,14-eicosatetraynoic acid (ETYA) and other inhibitors of the lipoxygenase pathway at concentrations that inhibited arachidonic acid metabolism in mixed lymphocyte cultures. Inhibition was reversible and selective for the "lethal hit" stage in the CTL-target interaction. Studies to define CTL-specific arachidonic acid metabolites demonstrated that cloned CTL populations have little or no capacity to metabolize arachidonic acid. Therefore, inhibitor actions appear to be independent of the effects on CTL arachidonic acid metabolism. Alternative explanations for inhibitory effects are discussed.
A S Taylor; R C Howe; A R Morrison; H Sprecher; J H Russell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  134     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-02-20     Completed Date:  1985-02-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1130-5     Citation Subset:  AIM; IM    
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MeSH Terms
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
5,8,11,14-Eicosatetraynoic Acid / pharmacology*
Arachidonic Acid
Arachidonic Acids / antagonists & inhibitors,  metabolism*
Binding, Competitive
Clone Cells / immunology,  metabolism
Cytotoxicity, Immunologic / drug effects*
Fatty Acids, Unsaturated / pharmacology*
Hydroxyeicosatetraenoic Acids / pharmacology
Leukotriene B4 / pharmacology
Lipoxygenase Inhibitors
Lymphocyte Culture Test, Mixed
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Inbred DBA
T-Lymphocytes, Cytotoxic / immunology*,  metabolism
Grant Support
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids, Unsaturated; 0/Hydroxyeicosatetraenoic Acids; 0/Lipoxygenase Inhibitors; 1191-85-1/5,8,11,14-Eicosatetraynoic Acid; 506-32-1/Arachidonic Acid; 59985-28-3/12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 71160-24-2/Leukotriene B4; 73945-47-8/15-hydroxy-5,8,11,13-eicosatetraenoic acid

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