| Inhibition of cyanide-insensitive respiration in Klebsiella oxytoca SYSU-011 by 8-hydroxyquinolone. | |
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MedLine Citation:
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PMID: 17277908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inhibition of the cyanide (KCN)-insensitive respiration of Klebsiella oxytoca SYSU-011 by 8-hydroxyquinoline (8-HQ) was determined. Results showed that the profile of the rate of oxygen uptake of normal-grown and 8-HQ-grown K. oxytoca SYSU-011 was biphasic and similar, suggesting that 8-HQ did not inhibit the respiration of normal-grown K. oxytoca SYSU-011. A different biphasic KCN inhibition profile of respiration was observed for KCN-grown cells treated with and without 8-HQ. No decrease in respiration rate of KCN-grown cells and a 40% decrease in respiration rate of KCN-grown cells treated with 8-HQ were observed when KCN concentration was 10(-1) mM. Comparing differences of the profiles of oxygen uptake in KCN-grown cells with and without 8-HQ addition indicated that 8-HQ inhibited expression of the KCN-insensitive pathway carried out by nonheme oxidase. Greater inhibition of NADH oxidase activity by 2-n-heptyl-4-hydroxyquinoline-N-oxide from the cell membrane of the KCN-grown cells treated with 8-HQ, and more H2O2 production from these cells with than without 8-HQ, suggest that the function of the cyanide-insensitive pathway can stabilize the respiration of the cyanide-grown cells to prevent the production of H2O2. |
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Authors:
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Chih Ming Kao; You Cheng Hseu; Yen Ling Huang; Peturs Tang; Ssu Ching Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current microbiology Volume: 54 ISSN: 0343-8651 ISO Abbreviation: Curr. Microbiol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-07-04 Completed Date: 2007-08-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7808448 Medline TA: Curr Microbiol Country: United States |
Other Details:
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Languages: eng Pagination: 190-4 Citation Subset: IM |
Affiliation:
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Institute of Environmental Engineering, National SunYat-Sen University, Kaohsiung, Taiwan, ROC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology* Hydrogen Peroxide / metabolism Klebsiella oxytoca / drug effects*, enzymology, metabolism* Multienzyme Complexes / antagonists & inhibitors NADH, NADPH Oxidoreductases / antagonists & inhibitors Oxidoreductases / antagonists & inhibitors Oxygen / metabolism Oxygen Consumption / drug effects* Oxyquinoline / pharmacology* Potassium Cyanide / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Multienzyme Complexes; 148-24-3/Oxyquinoline; 151-50-8/Potassium Cyanide; 7722-84-1/Hydrogen Peroxide; 7782-44-7/Oxygen; EC 1.-/Oxidoreductases; EC 1.6.-/NADH oxidase; EC 1.6.-/NADH, NADPH Oxidoreductases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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