Document Detail

Inhibition of cyanide-insensitive respiration in Klebsiella oxytoca SYSU-011 by 8-hydroxyquinolone.
MedLine Citation:
PMID:  17277908     Owner:  NLM     Status:  MEDLINE    
The inhibition of the cyanide (KCN)-insensitive respiration of Klebsiella oxytoca SYSU-011 by 8-hydroxyquinoline (8-HQ) was determined. Results showed that the profile of the rate of oxygen uptake of normal-grown and 8-HQ-grown K. oxytoca SYSU-011 was biphasic and similar, suggesting that 8-HQ did not inhibit the respiration of normal-grown K. oxytoca SYSU-011. A different biphasic KCN inhibition profile of respiration was observed for KCN-grown cells treated with and without 8-HQ. No decrease in respiration rate of KCN-grown cells and a 40% decrease in respiration rate of KCN-grown cells treated with 8-HQ were observed when KCN concentration was 10(-1) mM. Comparing differences of the profiles of oxygen uptake in KCN-grown cells with and without 8-HQ addition indicated that 8-HQ inhibited expression of the KCN-insensitive pathway carried out by nonheme oxidase. Greater inhibition of NADH oxidase activity by 2-n-heptyl-4-hydroxyquinoline-N-oxide from the cell membrane of the KCN-grown cells treated with 8-HQ, and more H2O2 production from these cells with than without 8-HQ, suggest that the function of the cyanide-insensitive pathway can stabilize the respiration of the cyanide-grown cells to prevent the production of H2O2.
Chih Ming Kao; You Cheng Hseu; Yen Ling Huang; Peturs Tang; Ssu Ching Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current microbiology     Volume:  54     ISSN:  0343-8651     ISO Abbreviation:  Curr. Microbiol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-07-04     Completed Date:  2007-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7808448     Medline TA:  Curr Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-4     Citation Subset:  IM    
Institute of Environmental Engineering, National SunYat-Sen University, Kaohsiung, Taiwan, ROC.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Hydrogen Peroxide / metabolism
Klebsiella oxytoca / drug effects*,  enzymology,  metabolism*
Multienzyme Complexes / antagonists & inhibitors
NADH, NADPH Oxidoreductases / antagonists & inhibitors
Oxidoreductases / antagonists & inhibitors
Oxygen / metabolism
Oxygen Consumption / drug effects*
Oxyquinoline / pharmacology*
Potassium Cyanide / pharmacology*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Multienzyme Complexes; 148-24-3/Oxyquinoline; 151-50-8/Potassium Cyanide; 7722-84-1/Hydrogen Peroxide; 7782-44-7/Oxygen; EC 1.-/Oxidoreductases; EC 1.6.-/NADH oxidase; EC 1.6.-/NADH, NADPH Oxidoreductases

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