Document Detail

Inhibition of croton oil-induced oedema in mice ear skin by capsular polysaccharides from cyanobacteria.
MedLine Citation:
PMID:  10763863     Owner:  NLM     Status:  MEDLINE    
The anti-inflammatory properties of hydrophilic extracts of the capsular polymers of twelve cyanobacterial strains belonging to the genera Phormidium and Nostoc from marine and terrestrial habitats were tested topically on croton oil-induced oedema in mice ear skin. The screening program identified several strains as producers of anti-inflammatory products (up to 56% inhibition of the oedema). The inhibition response was dose-dependent. The application of trichloroacetic acid-treated extracts reduced the oedema by about 60%. On the other hand, one of the strains enhanced the inflammatory response. Analysis of five of the extracts showed the presence of neutral sugars (from 34.3% to 47.1%, w/w), uronic acids (from 7.1% to 26.7%, w/w) and proteins (from 30.1% to 57.0%, w/w) in the crude polymer. Rhamnose, fucose, arabinose, xylose, mannose, glucose, galactose, galacturonic acid and glucuronic acid were detected as well as sulphate groups (from 9.6% to 21.5%, w/w of sugars). The main components found were glucose and mannose.
N Garbacki; V Gloaguen; J Damas; L Hoffmann; M Tits; L Angenot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  361     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-09     Completed Date:  2000-05-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  460-4     Citation Subset:  IM    
Laboratoire de Pharmacognosie, Institut de Pharmacie, CHU, Tour 4, Université de Liège, Belgium.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Croton Oil
Cyanobacteria / chemistry*
Ear / pathology
Edema / chemically induced,  drug therapy*,  pathology
Polysaccharides / chemistry,  pharmacology*
Skin / pathology
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Polysaccharides; 8001-28-3/Croton Oil

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