| Inhibition of cell growth and induction of G1-phase cell cycle arrest in hepatoma cells by steroid extract from Meretrix meretrix. | |
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MedLine Citation:
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PMID: 16458116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we report that the steroid extract 5alpha, 8alpha-epidioxycholest-6-ene-3beta-ol (MME) from Meretrix meretrix has the ability to inhibit growth of hepatoma cells and to induce G1-phase cell cycle arrest in two human hepatoma cell lines, HepG2 and Hep3B. HepG2 cells were more sensitive than Hep3B to MME. The extract markedly up-regulated the expression of p53 and p21WAF1/CIP1 in HepG2, suggesting that MME-induced G1 phase cell cycle arrest in HepG2 might be p53-dependent. Therefore, the up-regulation of p27KIP1and p16INK4A in both cell lines indicates that a p53-independent pathway might be involved in the mechanism of MME inducing cell cycle arrest. In conclusion, MME induces G1 phase cell cycle arrest via both p53-dependent and p53-independent pathways. |
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Authors:
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Ting-He Wu; Ruo-Lin Yang; Li-Ping Xie; Hong-Zhong Wang; Lei Chen; Shuyi Zhang; Yong Zhao; Rong-Qing Zhang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer letters Volume: 232 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-06 Completed Date: 2006-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 199-205 Citation Subset: IM |
Affiliation:
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Laboratory of Marine Biotechnology, Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD95
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analysis Bivalvia / chemistry* Carcinoma, Hepatocellular / chemistry, drug therapy*, pathology Cell Line, Tumor Cell Proliferation / drug effects Cyclin-Dependent Kinase Inhibitor p16 / analysis Cyclin-Dependent Kinase Inhibitor p21 / analysis Cyclin-Dependent Kinase Inhibitor p27 / analysis G1 Phase / drug effects* Humans Intracellular Signaling Peptides and Proteins / analysis Liver Neoplasms / chemistry, drug therapy*, pathology Steroids / pharmacology* Tumor Suppressor Protein p53 / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/CDKN1A protein, human; 0/CDKN1B protein, human; 0/Cyclin-Dependent Kinase Inhibitor p16; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Intracellular Signaling Peptides and Proteins; 0/Steroids; 0/Tumor Suppressor Protein p53; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27 |
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