Document Detail

Inhibition of cell growth by Stellera chamaejasme extract is associated with induction of autophagy and differentiation in chronic leukemia K562 cells.
MedLine Citation:
PMID:  20547324     Owner:  NLM     Status:  MEDLINE    
Stellera chamaejasme has been used as a therapeutic plant for treatment of various inflammatory diseases and solid tumors. Our study was particularly interested in the differentiation inducing activity of the aerial parts of S.chamaejasme using human chronic leukemia cell line K562. The ethanol extract has been shown to be highly cytotoxic against K562 cells at >0.008% (v/v) doses. Cell cycle arrest at G(0)/G(1) phase, not detectable DNA fragmentation as well as positive staining with acridine orange and expression of beclin-1 protein in the treated cells led as to detect autophagic cell death during the plant extract treatment of K562 cells. Moreover, differentiation marker CD11b was also expressed in the treated cells.
Soninkhishig Tsolmon; Junkyu Han; Hiroko Isoda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-06
Journal Detail:
Title:  Journal of bioscience and bioengineering     Volume:  110     ISSN:  1347-4421     ISO Abbreviation:  J. Biosci. Bioeng.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-06     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888800     Medline TA:  J Biosci Bioeng     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  262-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.
Graduate School of Life and Environmental Sciences, University of Tsukuba,1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan.
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MeSH Terms
Autophagy / drug effects*
Cell Cycle / drug effects*
Cell Differentiation / drug effects
Cell Proliferation / drug effects
K562 Cells
Plant Extracts / pharmacology*
Stellaria / chemistry*
Reg. No./Substance:
0/Plant Extracts

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