Document Detail


Inhibition by kynurenine metabolites of proinsulin synthesis in isolated pancreatic islets.
MedLine Citation:
PMID:  373355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of kynurenine metabolites on insulin biosynthesis was investigated in isolated pancreatic islets of the rat. Both quinaldic acid and 8-hydroxyquinaldic acid were found to produce significant inhibition of the proinsulin synthesis. However, the conversion process of proinsulin to insulin in the islet was not affected by these kynurenine metabolites. Furthermore, the inhibitory effect of these end-metabolites of dynurenine was characterized by preferential inhibition of proinsulin synthesis as distinct from non-insulin protein synthesis in the islet. In contrast to the significant inhibitory effect of quinaldic acid and 8-hydroxyquinaldic acid on proinsulin synthesis, xanthurenic acid and kynurenic acid were far less effective, and L-tryptophan, L-kynurenine, 3-hydroxyanthranilic acid and quinolinic acid showed little ability to inhibit proinsulin synthesis in islets.
Authors:
Y Noto; H Okamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta diabetologica latina     Volume:  15     ISSN:  0001-5563     ISO Abbreviation:  Acta Diabetol Lat     Publication Date:    1978 Sep-Dec
Date Detail:
Created Date:  1979-06-11     Completed Date:  1979-06-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0123567     Medline TA:  Acta Diabetol Lat     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  273-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Culture Techniques
Depression, Chemical
Insulin / biosynthesis
Islets of Langerhans / metabolism*
Kynurenine / analogs & derivatives*,  pharmacology
Male
Proinsulin / biosynthesis*,  metabolism
Quinolines / pharmacology*
Rats
Tryptophan / pharmacology
Chemical
Reg. No./Substance:
0/Quinolines; 11061-68-0/Insulin; 343-65-7/Kynurenine; 73-22-3/Tryptophan; 9035-68-1/Proinsulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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