Document Detail


Inhibition by islet-activating protein, pertussis toxin, of retinoic acid-induced differentiation of human leukemic (HL-60) cells.
MedLine Citation:
PMID:  2551727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human promyelocytic leukemic (HL-60) cells were induced to differentiate into neutrophil- or macrophage-like cells by incubation of the cells with retinoic acid, dibutyryl cyclic AMP (Bt2cAMP) or phorbol 12-myristate 13-acetate (PMA). Differentiation was determined by an increase in the percentage of morphologically mature cells. The retinoic acid-induced differentiation of HL-60 cells was, but the Bt2cAMP- or PMA-induced one was not, inhibited by prior exposure of the cells to islet-activating protein (IAP), pertussis toxin. The IAP-induced inhibition was correlated with the toxin-catalyzed ADP-ribosylation of a membrane GTP-binding protein with a molecular mass of 40 kDa. Thus, the IAP-substrate GTP-binding protein appears to be involved in the retinoic acid-induced differentiation of HL-60 cells.
Authors:
M Tohkin; T Iiri; M Ui; T Katada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  255     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-11-09     Completed Date:  1989-11-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  IM    
Affiliation:
Department of Life Science, Faculty of Science, Tokyo Institute of Technology, Yokohama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate Ribose / metabolism
Catalysis
Cell Differentiation / drug effects
Cyclic AMP / pharmacology
Drug Interactions
GTP-Binding Proteins / metabolism,  physiology
Humans
Leukemia, Promyelocytic, Acute / metabolism,  pathology*
Pertussis Toxin*
Phorbol Esters / pharmacology
Tretinoin / antagonists & inhibitors,  pharmacology*
Tumor Cells, Cultured / drug effects
Virulence Factors, Bordetella / pharmacology*
Chemical
Reg. No./Substance:
0/Phorbol Esters; 0/Virulence Factors, Bordetella; 20762-30-5/Adenosine Diphosphate Ribose; 302-79-4/Tretinoin; 60-92-4/Cyclic AMP; EC 2.4.2.31/Pertussis Toxin; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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