| Inhibition by fatty acids of the cholesterol side-chain cleavage in the course of progesterone biosynthesis in the mitochondrial fraction of human term placenta. | |
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MedLine Citation:
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PMID: 6894995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Saturated and unsaturated fatty acids inhibit the progesterone biosynthesis from cholesterol in the human placenta mitochondrial fraction. 2. Inhibition of the progesterone biosynthesis by fatty acids could be relieved by ATP, CoA and carnitine. 3. The inhibitory effect of fatty acids is due to their action on the cholesterol side-chain mixed-function oxidase system but not on the NADPH-regenerating system. |
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Authors:
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B Tiałowska; J Klimek; L Zelewski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta biochimica Polonica Volume: 27 ISSN: 0001-527X ISO Abbreviation: Acta Biochim. Pol. Publication Date: 1980 |
Date Detail:
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Created Date: 1981-10-28 Completed Date: 1981-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 14520300R Medline TA: Acta Biochim Pol Country: POLAND |
Other Details:
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Languages: eng Pagination: 257-64 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholesterol Side-Chain Cleavage Enzyme
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metabolism* Fatty Acids, Nonesterified / pharmacology* Fatty Acids, Unsaturated / pharmacology Female Humans Mitochondria / drug effects, metabolism* Oxidoreductases / metabolism* Placenta / metabolism* Pregnancy Pregnenolone / biosynthesis Progesterone / biosynthesis* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 145-13-1/Pregnenolone; 57-83-0/Progesterone; EC 1.-/Oxidoreductases; EC 1.14.15.6/Cholesterol Side-Chain Cleavage Enzyme |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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