Document Detail


Inhibition by fatty acids of the cholesterol side-chain cleavage in the course of progesterone biosynthesis in the mitochondrial fraction of human term placenta.
MedLine Citation:
PMID:  6894995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Saturated and unsaturated fatty acids inhibit the progesterone biosynthesis from cholesterol in the human placenta mitochondrial fraction. 2. Inhibition of the progesterone biosynthesis by fatty acids could be relieved by ATP, CoA and carnitine. 3. The inhibitory effect of fatty acids is due to their action on the cholesterol side-chain mixed-function oxidase system but not on the NADPH-regenerating system.
Authors:
B Tiałowska; J Klimek; L Zelewski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  27     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-10-28     Completed Date:  1981-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  257-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cholesterol Side-Chain Cleavage Enzyme / metabolism*
Fatty Acids, Nonesterified / pharmacology*
Fatty Acids, Unsaturated / pharmacology
Female
Humans
Mitochondria / drug effects,  metabolism*
Oxidoreductases / metabolism*
Placenta / metabolism*
Pregnancy
Pregnenolone / biosynthesis
Progesterone / biosynthesis*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 145-13-1/Pregnenolone; 57-83-0/Progesterone; EC 1.-/Oxidoreductases; EC 1.14.15.6/Cholesterol Side-Chain Cleavage Enzyme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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