| Inhibition of branched-chain alpha-ketoacid dehydrogenase kinase by thiamine pyrophosphate at different potassium ionic levels. | |
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MedLine Citation:
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PMID: 19420697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhibition of branched-chain alpha-ketoacid dehydrogenase kinase (BDK) by thiamine pyrophosphate (TPP) was analyzed at two potassium ion (K(+)) concentrations. IC(50) values of 4.6 and 8.0 microM and inhibition constant values of 3.2 and 16.4 microM were obtained in the presence of 20 and 100 mM K(+), respectively. These results suggest that BDK is less sensitive to TPP inhibition under physiological TPP and K(+) concentrations. |
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Authors:
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Keiichi Akita; Yukihiro Fujimura; Gustavo Bajotto; Yoshiharu Shimomura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 73 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-08-28 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 1189-91 Citation Subset: IM |
Affiliation:
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Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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pharmacology Dose-Response Relationship, Drug Inhibitory Concentration 50 Kinetics Potassium / pharmacology* Protein Kinase Inhibitors / pharmacology* Protein Kinases / metabolism* Thiamine Pyrophosphate / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Protein Kinase Inhibitors; 154-87-0/Thiamine Pyrophosphate; 56-65-5/Adenosine Triphosphate; 7440-09-7/Potassium; EC 2.7.-/Protein Kinases; EC 2.7.1.115/(3-methyl-2-oxobutanoate dehydrogenase (lipoamide)) kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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