Document Detail


Inhibition of bone marrow myelopoiesis and erythropoiesis in vitro by anti-retroviral nucleoside derivatives.
MedLine Citation:
PMID:  2847772     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied the in vitro effects of nucleoside inhibitors of reverse transcriptase on bone marrow myeloid and erythroid progenitor development. Both 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (DDC) potently inhibited in vitro haematopoiesis, while 2',3'-dideoxyadenosine (DDA) was less inhibitory in this culture system. Studies of candidate antiretroviral agents in bone marrow culture may predict clinical toxicity as well as lead to strategies for combination therapy which minimize impairment of haematopoiesis.
Authors:
M Johnson; T Caiazzo; J M Molina; R Donahue; J Groopman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of haematology     Volume:  70     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-23     Completed Date:  1988-12-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  137-41     Citation Subset:  IM; X    
Affiliation:
Department of Medicine, New England Deaconess Hospital, Harvard Medical School, Boston, Mass. 02215.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / physiopathology
Bone Marrow / drug effects*
Cells, Cultured
Colony-Forming Units Assay
Depression, Chemical
Dideoxynucleosides / pharmacology*
Erythropoiesis / drug effects*
Humans
Zalcitabine
Zidovudine / pharmacology*
Grant Support
ID/Acronym/Agency:
AI/HL24475/AI/NIAID NIH HHS; HL33774/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Dideoxynucleosides; 30516-87-1/Zidovudine; 7481-89-2/Zalcitabine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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