| Inhibition of blood platelet adhesion and secretion by different phenolics from Yucca schidigera Roezl. bark. | |
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MedLine Citation:
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PMID: 15723749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Yucca schidigera is a plant that grows in Mexico, and it has a very high level of saponins and phenolic compounds with antioxidant action. The products of Y. schidigera are used as food additives and have a generally recognized as safe label. This study investigated the antiplatelet mechanisms of four phenolic compounds. METHODS: We investigated antiplatelet mechanisms of the phenolic compounds trans-3,4',5-trihydroxystilbene (trans-resveratrol), trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene, and yuccaols A and C that had been isolated from the bark of Y. schidigera by studying their effects on the first step of platelet activation, i.e., platelet adhesion to collagen and fibrinogen. The effects of these compounds on the release of adenine nucleotides, proteins, and beta-N-acetyl-glycosaminidase (a marker of lysosomal secretion) from blood platelets activated by thrombin were also studied. RESULTS: These different phenolic compounds (1 to 25 microg/mL) and their extracts decreased platelet adhesion and secretion. CONCLUSIONS: Resveratrol and yucca extract were more reactive in decreasing these processes than were other tested phenolic compounds. |
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Authors:
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Beata Olas; Barbara Wachowicz; Anna Stochmal; Wieslaw Oleszek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 21 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-02-22 Completed Date: 2005-05-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 199-206 Citation Subset: IM |
Affiliation:
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Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Platelets / drug effects*, metabolism Cells, Cultured Collagen / metabolism Dose-Response Relationship, Drug Fibrinogen / metabolism Phenols / pharmacology* Plant Extracts / pharmacology* Platelet Adhesiveness / drug effects* Platelet Aggregation Inhibitors / pharmacology* Stilbenes / pharmacology Swine Yucca / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Phenols; 0/Plant Extracts; 0/Platelet Aggregation Inhibitors; 0/Stilbenes; 501-36-0/resveratrol; 9001-32-5/Fibrinogen; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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