| Inhibition of basal and insulin-stimulated gastric acid secretion by phenoxybenzamine or phentolamine. | |
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MedLine Citation:
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PMID: 2886629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study in the rat was undertaken to investigate the possible involvement of alpha- and beta-adrenoceptors in mediating gastric acid secretion in response to insulin-hypoglycaemia. Phenoxybenzamine, 15 mg kg-1, depressed the basal acid secretion to a level similar to that associated with vagotomy; phentolamine, 15 mg kg-1, had a similar effect. Insulin (1 unit kg-1) significantly stimulated gastric acid secretion. Vagotomy or phenoxybenzamine or phentolamine, 15 mg kg-1 prevented this action. The beta-adrenoceptor blocking drug, propranolol, 5-15 mg kg-1, had no significant effect on the basal acid secretion or its stimulation by insulin. The similarity in action between vagotomy and large doses of phenoxybenzamine and phentolamine suggests that, in the rat, vagal alpha-adrenoceptor stimulation is involved in the mechanisms of basal and insulin-stimulated gastric acid secretion. |
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Authors:
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A S Salim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 39 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1987-09-14 Completed Date: 1987-09-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 562-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Cimetidine / pharmacology Female Gastric Acid / secretion* Insulin / pharmacology* Male Phenoxybenzamine / pharmacology* Phentolamine / pharmacology* Rats Receptors, Adrenergic / physiology Serotonin / secretion Vagus Nerve / physiology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 11061-68-0/Insulin; 50-60-2/Phentolamine; 50-67-9/Serotonin; 51-55-8/Atropine; 51481-61-9/Cimetidine; 59-96-1/Phenoxybenzamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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