Document Detail

Inhibition of bacterial attachment to kidney epithelial cells using thymoquinone - biomed 2010.
MedLine Citation:
PMID:  20467074     Owner:  NLM     Status:  In-Data-Review    
Lancefield group A streptococci consists of a Streptococcus pyogens (GAS), which is associated with variety of superlative infections. GAS has the capacity to trigger post infectious syndromes of acute rheumatic fever and post streptococcal glomerulonephritis. GAS is one of the most common human pathogens, and is the most frequent cause of acute pharyngitis (strep throat). GAS can progress very rapidly and lead to soft tissue necrosis, acute kidney failure, adult respiratory distress syndrome, disseminated intravascular coagulopathy, and multi-organ failure and ultimately shock and death [1]. The purpose of this study was to determine if pre-treating or post-treating RMKEC with TQ would alter GASs ability to adhere to the host cells. Results: The findings from our study indicate that the cells pretreated with TQ (10microM, 50microM, or 100microM) decreased the number of bacteria that were able to attach to the cells in a dose dependent manner. The cells post treated with TQ (10microM, 50microM, or 100microM) decreased the number of bacteria that were able to attach to the cells in a dose dependent manner and was found to be directly proportional to the TQ concentrations. The administration of TQ 10 microM was the most effective in preventing the attachment of GAS to pre-treated and post-treated epithelial cells in vitro.
Stacy Hull Vance; Hamed Benghuzzi; Michelle Tucci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedical sciences instrumentation     Volume:  46     ISSN:  0067-8856     ISO Abbreviation:  Biomed Sci Instrum     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0140524     Medline TA:  Biomed Sci Instrum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-74     Citation Subset:  IM    
University of Mississippi Medical Center, Jackson, Mississippi.
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