| Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells. | |
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MedLine Citation:
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PMID: 22019047 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The function of autophagy in cisplatin-treated cancer cells is not fully understood. Cisplatin treatment induced degradation of ubiquitinated proteins by autophagy, which reduced apoptosis induced by endoplasmic reticulum (ER) stress and downregulated the mitochondrial pathway of apoptosis. Inhibition of autophagy using 3-methyladenine (3-MA) or chloroquine (CQ) increased the levels of intracellular misfolded proteins, which enhanced cellular apoptosis. We found that tunicamycin, an ER stress inducer, augmented cisplatin cytotoxicity by upregulating ER stress-mediated apoptosis. Our data indicates that autophagy plays an important role in preventing cisplatin-induced apoptosis in HeLa cells, thus inhibition of autophagy may improve cisplatin chemotherapy. |
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Authors:
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Ye Xu; Huimei Yu; Hanjiao Qin; Jinsong Kang; Chunyan Yu; Jiateng Zhong; Jing Su; Hongyan Li; Liankun Sun |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-2 |
Journal Detail:
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Title: Cancer letters Volume: - ISSN: 1872-7980 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China; Medical Research Laboratory, Jilin Medical College, Jilin City 132013, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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