| Inhibition of arachidonic acid induced mortality in rabbits with several non-steroidal anti-inflammatory agents. | |
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MedLine Citation:
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PMID: 930759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intravenous administration of arachidonic acid to rabbits is an effective in vivo model for evaluating potential anti-thrombotic drugs. Most of the non-steroidal anti-inflammatory agents (NSAIFA) inhibit this arachidonic acid induced mortality (except sodium salicylate and acetaminophen). However, there is a lack of correlation between the relative potencies from various assays (rabbit anti-thrombotic, anti-inflammatory, alalgesic, ulcerogenic and inhibition of prostaglandin synthetase evaluations). These studies imply other actions with NSAIFA than an effect solely on the prostaglandin biosynthetic pathway. |
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Authors:
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G DiPasquale; D Mellace |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Agents and actions Volume: 7 ISSN: 0065-4299 ISO Abbreviation: Agents Actions Publication Date: 1977 Oct |
Date Detail:
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Created Date: 1978-01-27 Completed Date: 1978-01-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213341 Medline TA: Agents Actions Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 481-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / pharmacology* Arachidonic Acids / antagonists & inhibitors*, toxicity Lethal Dose 50 Male Prostaglandins / biosynthesis Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Arachidonic Acids; 0/Prostaglandins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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