Document Detail

Inhibition of arachidonic acid induced mortality in rabbits with several non-steroidal anti-inflammatory agents.
MedLine Citation:
PMID:  930759     Owner:  NLM     Status:  MEDLINE    
The intravenous administration of arachidonic acid to rabbits is an effective in vivo model for evaluating potential anti-thrombotic drugs. Most of the non-steroidal anti-inflammatory agents (NSAIFA) inhibit this arachidonic acid induced mortality (except sodium salicylate and acetaminophen). However, there is a lack of correlation between the relative potencies from various assays (rabbit anti-thrombotic, anti-inflammatory, alalgesic, ulcerogenic and inhibition of prostaglandin synthetase evaluations). These studies imply other actions with NSAIFA than an effect solely on the prostaglandin biosynthetic pathway.
G DiPasquale; D Mellace
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Agents and actions     Volume:  7     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  481-5     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents / pharmacology*
Arachidonic Acids / antagonists & inhibitors*,  toxicity
Lethal Dose 50
Prostaglandins / biosynthesis
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Arachidonic Acids; 0/Prostaglandins

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