| Inhibition of arachidonic acid cyclo-oxygenase and lipoxygenase activities of leukocytes by indomethacin and compound BW755C. | |
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MedLine Citation:
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PMID: 6791482 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arachidonic acid is metabolized via two pathways in leukocytes: cyclo-oxygenase, leading to the stable prostaglandins, and lipoxygenase, leading to hydroxyacids. Indomethacin inhibits the cyclo-oxygenase selectively, whereas compound BW755C (3-amino-1-(m-(trifluoromethyl)phenyl)-2-pyrazoline) inhibits both pathways equally. This offers a possible explanation for the differing activities of these two compounds in inflammatory models in vivo. The patterns of product inhibition by the two compounds support the suggestion that 11-HETE (hydroxy-eicosate-traenoic acid) and 15-HETE can arise by incomplete operation of the cyclo-oxygenase pathway. |
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Authors:
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R W Randall; K E Eakins; G A Higgs; J A Salmon; J E Tateson |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Agents and actions Volume: 10 ISSN: 0065-4299 ISO Abbreviation: Agents Actions Publication Date: 1980 Dec |
Date Detail:
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Created Date: 1981-10-29 Completed Date: 1981-10-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0213341 Medline TA: Agents Actions Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 553-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine Animals Anti-Inflammatory Agents / pharmacology* Arachidonic Acids / biosynthesis, metabolism Cyclooxygenase Inhibitors* Indomethacin / pharmacology* Leukocytes / enzymology* Lipoxygenase Inhibitors* Pyrazoles / pharmacology* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Arachidonic Acids; 0/Cyclooxygenase Inhibitors; 0/Lipoxygenase Inhibitors; 0/Pyrazoles; 53-86-1/Indomethacin; 59985-28-3/12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 66000-40-6/4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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