| Inhibition of apomorphine-induced yawning and penile erection by neurotensin. | |
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MedLine Citation:
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PMID: 1788138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The yawns and penile erection elicited in rats by apomorphine (100 micrograms/kg SC) are dose-dependently suppressed by the enkephalinase-resistant analog of NT, [D-Trp11]NT, intracerebroventricularly (ICV) injected (10-120 ng per rat). This antagonistic effect was shared by NT (0.75-3 micrograms per rat) administered ICV. The yawns induced by pilocarpine (2 mg/kg IP) were similarly antagonized by [D-Trp11]NT (30-120 ng per rat). The enkephalinase inhibitor acetorphan (5 mg/kg IV) reduced in a naloxone (2 mg/kg, SC)-resistant manner the apomorphine-induced penile erection or yawning. |
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Authors:
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D Nouel; J Costentin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Peptides Volume: 12 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1991 Jul-Aug |
Date Detail:
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Created Date: 1992-03-24 Completed Date: 1992-03-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 755-9 Citation Subset: IM |
Affiliation:
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European Institute for Peptide Research, Unité de Neuropsychopharmacologie Expérimentale U.R.A. 1170 du C.N.R.S., Faculté de Médecine et Pharmacie de Rouen, Saint Etienne Du Rouvray, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apomorphine / antagonists & inhibitors, pharmacology* Drug Antagonism Male Naloxone / pharmacology Neprilysin / antagonists & inhibitors, metabolism Neurotensin / pharmacology* Penile Erection / drug effects* Rats Rats, Inbred Strains Thiorphan / analogs & derivatives, pharmacology Yawning / drug effects* |
| Chemical | |
Reg. No./Substance:
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39379-15-2/Neurotensin; 465-65-6/Naloxone; 58-00-4/Apomorphine; 76721-89-6/Thiorphan; 81110-73-8/acetorphan; EC 3.4.24.11/Neprilysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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