| Inhibition of anaphylaxis like reaction and mast cell activation by Sitagliptin. | |
| | |
MedLine Citation:
|
PMID: 21382532 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Mast cells stimulation activates degranulation process resulting in releasing of mediators, such as histamine. In this study, the effect of aqueous extract of sitagliptin, a selective dipeptidylpeptidase-4 inhibitor, on the mast cell-mediated allergic response was studied with the possible mechanisms of action, focusing on the histamine release and pro-inflammatory cytokine secretion in mast cells. Sitagliptin produced dose dependent inhibition in compound 48/80-induced systemic reactions. In addition, sitagliptin attenuated IgE-mediated skin allergic reaction. Sitagliptin dose-dependently reduced compound 48/80- and IgE-induced histamine release from mast cells. Sitagliptin decreased the secretion of pro-inflammatory cytokines, tumor necrosis factor-α, in mast cells. So, the finding of this study provides evidence that sitagliptin inhibits mast cell derived allergic reactions, and involvement of pro-inflammatory cytokine secretion in such effects. |
| | |
Authors:
|
Manar A Nader |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-4 |
Journal Detail:
|
Title: International immunopharmacology Volume: - ISSN: 1878-1705 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier B.V. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative Cell Behavior on Carbon Coated TiO(2) Nanotube Surfaces for Osteoblasts vs. Osteo-progen...
Next Document: Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling.