| Inhibition of the alternative pathway of complement by glomerular chondroitin sulphate proteoglycan. | |
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MedLine Citation:
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PMID: 1382039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cultured rat glomerular epithelial cells (GEC) synthesize and secrete a complement inhibitory chondroitin sulphate B proteoglycan (termed GCRF). As proteoglycans and their component glycosaminoglycans may affect several different steps of complement activation, the functional properties of GCRF were investigated in this study. GCRF inhibited preformed alternative pathway convertases (C3bBbP), but did not substantially accelerate their decay. In contrast to other polyanions, GCRF did not affect the activity of human or rat factor H, nor did it inhibit the terminal complement proteins. GCRF inhibited the effect of decay-accelerating factor (DAF) on C3bBbP when the two were incubated together and DAF was in excess, but it did not affect the decay of DAF of classical pathway convertases. However, when DAF was first incorporated into the erythrocyte membrane, the effect of GCRF on C3bBbP was additive to that of DAF. Thus, GCRF inhibits the activity of C3bBbP and blocks the action of DAF, but not that of factor H, perhaps by binding to factor B in the alternative pathway convertase. |
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Authors:
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R J Quigg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Immunology Volume: 76 ISSN: 0019-2805 ISO Abbreviation: Immunology Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-10-19 Completed Date: 1992-10-19 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 373-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Medical College of Virginia, Richmond 23298. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD55 Complement C3-C5 Convertases / drug effects Complement Inactivator Proteins / drug effects Complement Membrane Attack Complex / drug effects Complement Pathway, Alternative / drug effects* Complement Pathway, Classical / drug effects Fibrinogen Kidney Glomerulus / metabolism Membrane Glycoproteins / drug effects Proteochondroitin Sulfates / pharmacology* Rats |
| Grant Support | |
ID/Acronym/Agency:
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DK 41873/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD55; 0/Complement Inactivator Proteins; 0/Complement Membrane Attack Complex; 0/Membrane Glycoproteins; 0/Proteochondroitin Sulfates; 9001-32-5/Fibrinogen; EC 3.4.21.-/Complement C3-C5 Convertases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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