Document Detail

Inhibition of adrenal steroidogenesis, food restriction and acclimation to high ambient temperatures in chickens.
MedLine Citation:
PMID:  7953785     Owner:  NLM     Status:  MEDLINE    
1. White Plymouth Rock chickens placed under 60% food restriction or ad libitum feeding, with or without metyrapone treatment, from either 4 to 6 (early) or 24 to 26 (late) d of age were exposed to high ambient temperatures (35 +/- 2 degrees C) from 36 to 43 d of age. 2. Stress attributable to fasting was not manifested through leucocytic alteration when food-restricted chicks were supplemented with an adrenal blocking chemical, metyrapone. 3. Provision of metyrapone during the fasting period resulted in inferior compensatory growth during refeeding. 4. Exposure to high temperatures from 36 to 43 d of age did not cause an elevation in the heterophil:lymphocyte (H/L) ratios of chicks that had eaten metyrapone-treated food ad libitum during the neonatal stage. 5. During heat exposure, chicks that had been subjected to early 60% restriction with non-metyrapone-treated food had lower H/L ratios and improved resistance to marble spleen disease infection.
I Zulkifli; E A Dunnington; W B Gross; P B Siegel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British poultry science     Volume:  35     ISSN:  0007-1668     ISO Abbreviation:  Br. Poult. Sci.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  15740290R     Medline TA:  Br Poult Sci     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  417-26     Citation Subset:  IM    
Animal and Poultry Sciences Department, Virginia Polytechnic Institute and State University, Blacksburg 24061-0306.
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MeSH Terms
Adrenal Cortex / drug effects*
Animal Feed
Body Weight* / drug effects
Chickens / physiology*
Diet, Reducing
Glucocorticoids / antagonists & inhibitors
Hot Temperature
Leukocyte Count / drug effects
Metyrapone / administration & dosage,  pharmacology*
Sex Characteristics
Time Factors
Reg. No./Substance:
0/Glucocorticoids; 54-36-4/Metyrapone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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