Document Detail

Inhibition of adjuvant arthritis in the rat by an oxonate diet: sequential studies.
MedLine Citation:
PMID:  604476     Owner:  NLM     Status:  MEDLINE    
To study the mechanism by which oxonate-induced hyperuricemia inhibits the development of adjuvant arthritis in the rat, we initiated blocking or releasing experiments by changing the oxonate diet of rats at selected times. We were able to define oxonate dietary effects on four specific periods in the development of this experimental arthritis. The inhibition of the primary inflammation at the site of the injection was weak. The inhibition of the secondary reaction was greater than the decrease of the primary inflammation and was more effective when the first two periods (sensitization to antigen and production of immunocompetent cells) were blocked. The reduction in the disease was more marked in the non-injected paw than in the injected paw. Thus, the effect of the oxonate diet is more immunosuppressive than anti-inflammatory. Release of the first period, which provoked an unexpected increase in the severity of the disease, suggests a possible influence of oxonate on pyrimidine metabolism.
A Lussier; R de Medicis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  4     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1977  
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  369-76     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents / pharmacology
Arthritis / immunology*
Arthritis, Experimental / immunology*
Immunosuppressive Agents / pharmacology
Oxonic Acid / administration & dosage,  pharmacology*
Pyrimidines / metabolism
Triazines / pharmacology*
Uremia / immunology
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 0/Pyrimidines; 0/Triazines; 937-13-3/Oxonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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