| Inhibition of acyl-CoA cholesterol acyltransferase by F12511 (Eflucimibe): could it be a new antiatherosclerotic therapeutic? | |
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MedLine Citation:
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PMID: 18466422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipid-lowering strategies, particularly with statins, have been extremely useful in the prevention of cardiovascular disease. However, many patients who receive statin monotherapy do not achieve the desired cardiovascular benefits. Accumulation of cholesteryl esters within macrophages constitutes the hallmark of foam cells during atherogenesis. The action of acyl-coenzyme A (CoA): cholesterol acyltransferase (ACAT) leads to formation of cholesterol esters. There are two different ACAT isoforms: ACAT1 and ACAT2. A considerable interest to develop ACAT inhibitors has been emerging. This review has been focused on the current knowledge about a new ACAT inhibitor, F12511 or eflucimibe, and more particularly on its antiatherosclerotic properties. |
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Authors:
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Antonio José López-Farré; Daniel Sacristán; José J Zamorano-León; Nuria San-Martín; Carlos Macaya |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cardiovascular therapeutics Volume: 26 ISSN: 1755-5914 ISO Abbreviation: - Publication Date: 2008 |
Date Detail:
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Created Date: 2008-05-09 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101319630 Medline TA: Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 65-74 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Unit, Cardiovascular Institute, Hospital Clínico San Carlos, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anilides
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chemistry,
pharmacology*,
therapeutic use*,
toxicity Animals Atherosclerosis / drug therapy* Clinical Trials as Topic Enzyme Inhibitors / chemistry, pharmacology*, therapeutic use*, toxicity Humans Sterol O-Acyltransferase / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Anilides; 0/Enzyme Inhibitors; 202340-45-2/eflucimibe; EC 2.3.1.26/Sterol O-Acyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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