Document Detail

Inhibition of acidic sphingomyelinase by xanthone compounds isolated from Garcinia speciosa.
MedLine Citation:
PMID:  10938539     Owner:  NLM     Status:  MEDLINE    
Sphingomyelinase is considered to be involved in the regulation of apoptosis and cell growth. In the course of our screening for acidic sphingomyelinase inhibitors we isolated three xanthone compounds, alpha-mangostin, cowanin, and cowanol, from the bark of Garcinia speciosa. These compounds competitively inhibited bovine brain-derived acidic sphingomyelinase with IC(50) values of 14.1, 19.2, and 10.9 microM, respectively and inhibited the acidic sphingomyelinase more effectively than the neutral sphingomyelinase of bovine brain. alpha-Mangostin inhibited the acidic sphingomyelinase in the most selective manner. alpha-Mangostin was chemically modified and its structure-activity relationships are discussed.
C Okudaira; Y Ikeda; S Kondo; S Furuya; Y Hirabayashi; T Koyano; Y Saito; K Umezawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of enzyme inhibition     Volume:  15     ISSN:  8755-5093     ISO Abbreviation:  J. Enzym. Inhib.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-26     Completed Date:  2003-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8709734     Medline TA:  J Enzyme Inhib     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  129-38     Citation Subset:  IM    
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-0061, Japan.
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MeSH Terms
4-Chloro-7-nitrobenzofurazan / analogs & derivatives*,  metabolism
Garcinia / metabolism*
Protein Kinase Inhibitors
Sphingomyelin Phosphodiesterase / antagonists & inhibitors*
Sphingomyelins / metabolism
Structure-Activity Relationship
Xanthenes / pharmacology*
Reg. No./Substance:
0/N-4-nitrobenzo-2-oxa-1,3-diazoleaminocaproyl sphingosylphosphorylcholine; 0/Protein Kinase Inhibitors; 0/Sphingomyelins; 0/Xanthenes; 0/Xanthones; 10199-89-0/4-Chloro-7-nitrobenzofurazan; 6147-11-1/mangostin; EC Phosphodiesterase

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