Document Detail


Inhibition of acidic sphingomyelinase by xanthone compounds isolated from Garcinia speciosa.
MedLine Citation:
PMID:  10938539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sphingomyelinase is considered to be involved in the regulation of apoptosis and cell growth. In the course of our screening for acidic sphingomyelinase inhibitors we isolated three xanthone compounds, alpha-mangostin, cowanin, and cowanol, from the bark of Garcinia speciosa. These compounds competitively inhibited bovine brain-derived acidic sphingomyelinase with IC(50) values of 14.1, 19.2, and 10.9 microM, respectively and inhibited the acidic sphingomyelinase more effectively than the neutral sphingomyelinase of bovine brain. alpha-Mangostin inhibited the acidic sphingomyelinase in the most selective manner. alpha-Mangostin was chemically modified and its structure-activity relationships are discussed.
Authors:
C Okudaira; Y Ikeda; S Kondo; S Furuya; Y Hirabayashi; T Koyano; Y Saito; K Umezawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of enzyme inhibition     Volume:  15     ISSN:  8755-5093     ISO Abbreviation:  J. Enzym. Inhib.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-26     Completed Date:  2003-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8709734     Medline TA:  J Enzyme Inhib     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  129-38     Citation Subset:  IM    
Affiliation:
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-0061, Japan.
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MeSH Terms
Descriptor/Qualifier:
4-Chloro-7-nitrobenzofurazan / analogs & derivatives*,  metabolism
Acetylation
Animals
Cattle
Garcinia / metabolism*
Protein Kinase Inhibitors
Sphingomyelin Phosphodiesterase / antagonists & inhibitors*
Sphingomyelins / metabolism
Structure-Activity Relationship
Xanthenes / pharmacology*
Xanthones*
Chemical
Reg. No./Substance:
0/N-4-nitrobenzo-2-oxa-1,3-diazoleaminocaproyl sphingosylphosphorylcholine; 0/Protein Kinase Inhibitors; 0/Sphingomyelins; 0/Xanthenes; 0/Xanthones; 10199-89-0/4-Chloro-7-nitrobenzofurazan; 6147-11-1/mangostin; EC 3.1.4.12/Sphingomyelin Phosphodiesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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