Document Detail

Inhibition of Western-diet induced hyperproliferation and hyperplasia in mouse colon by two sources of calcium.
MedLine Citation:
PMID:  7586187     Owner:  NLM     Status:  MEDLINE    
A Western-style diet containing high-fat and phosphate, and low calcium and vitamin D was fed to mice for 20 weeks. Starting at week 8, subgroups of animals received the Western-style diet supplemented by two different calcium sources: tricalcium phosphate and calcium citrate malate. Hyperproliferation (increased [3H]thymidine-labelled cells/colonic crypt) and hyperplasia (increased total epithelial cells/crypt) developed in the sigmoid colon after 8 weeks of feeding the Western-style diet confirming previous results, and these were reversed at later periods by the addition of the two calcium sources to the Western-style diet. Findings indicate that the modified colonic epithelial cell hyperproliferation and hyperplasia which have been associated with subsequent development of colonic neoplasia, are induced in mice fed a Western-style diet, and the addition of calcium to the diet inhibited their development in the colonic mucosa.
F Richter; H L Newmark; A Richter; D Leung; M Lipkin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Carcinogenesis     Volume:  16     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-28     Completed Date:  1995-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2685-9     Citation Subset:  IM    
Irving Weinstein Laboratory for Gastrointestinal Cancer Prevention, Gastroenterology and Nutrition Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
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MeSH Terms
Calcium, Dietary / administration & dosage*
Cell Division
Colon / pathology*
Colonic Neoplasms / etiology
Dietary Fats / adverse effects*
Mice, Inbred C57BL
Phosphates / administration & dosage,  adverse effects*
Vitamin D / administration & dosage*
Reg. No./Substance:
0/Calcium, Dietary; 0/Dietary Fats; 0/Phosphates; 1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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