Document Detail


Inhibition and Termination of Physiological Responses by GTPase Activating Proteins.
MedLine Citation:
PMID:  22298657     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Physiological processes are strictly organized in space and time. However, in cell physiology research, more attention is given to the question of space rather than to time. To function as a signal, environmental changes must be restricted in time; they need not only be initiated but also terminated. In this review, we concentrate on the role of one specific protein family involved in biological signal termination. GTPase activating proteins (GAPs) accelerate the endogenously low GTP hydrolysis rate of monomeric guanine nucleotide-binding proteins (GNBPs), limiting thereby their prevalence in the active, GTP-bound form. We discuss cases where defective or excessive GAP activity of specific proteins causes significant alteration in the function of the nervous, endocrine, and hemopoietic systems, or contributes to development of infections and tumors. Biochemical and genetic data as well as observations from human pathology support the notion that GAPs represent vital elements in the spatiotemporal fine tuning of physiological processes.
Authors:
Erzsébet Ligeti; Stefan Welti; Klaus Scheffzek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiological reviews     Volume:  92     ISSN:  1522-1210     ISO Abbreviation:  Physiol. Rev.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231714     Medline TA:  Physiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  237-72     Citation Subset:  IM    
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