| Inhibition of T cell-mediated cytotoxicity by anti-inflammatory steroids. | |
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MedLine Citation:
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PMID: 6606668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have tested the capacity of glucocorticoids to modulate the effector function of splenic cytotoxic T lymphocytes (CTL) obtained after i.p. immunization with allogeneic cells. Although acute exposure to glucocorticoids did not inhibit the activity of freshly obtained splenic CTL, preincubation of these CTL for several hours with subnanomolar concentrations of several different glucocorticoids caused marked inhibition. The relative inhibitory potency of the steroids tested correlated with their reported activity both in glucocorticoid receptor binding assays and in assays of anti-inflammatory potency in man. The inhibitory effects of low concentrations (10(-10) M to 10(-9) M) of dexamethasone were reversed by human or mouse interleukin 2 (IL 2)-containing supernatants, but were not reversed by IL 1-containing supernatants. The inhibitory effects of higher concentrations (10(-8) M to 10(-7) M) of dexamethasone could not be reversed even by very high doses of mouse IL 2. In contrast to previous reports of minimal direct glucocorticoid effects on CTL activity, the present results suggest that after preincubation, splenic CTL from in vivo-immune mice are sensitive to inhibition by glucocorticoids, and that the glucocorticoids may act both indirectly (on IL 2 production) and directly on the CTL. |
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Authors:
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R P Schleimer; A Jacques; H S Shin; L M Lichtenstein; M Plaut |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 132 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 266-71 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Anti-Inflammatory Agents / pharmacology* Cytotoxicity, Immunologic / drug effects* Dexamethasone / analogs & derivatives, pharmacology Dose-Response Relationship, Drug Humans Immunosuppressive Agents / pharmacology* Interleukin-2 / physiology Kinetics Lymphocyte Activation / drug effects Mice Mice, Inbred C57BL T-Lymphocytes, Cytotoxic / drug effects, immunology* Triamcinolone Acetonide / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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AI 12810/AI/NIAID NIH HHS; AI 20136/AI/NIAID NIH HHS; HL 23586/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 0/Interleukin-2; 1177-87-3/dexamethasone acetate; 50-02-2/Dexamethasone; 76-25-5/Triamcinolone Acetonide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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