Document Detail


Inhibition of Salmonella typhi Growth Using Extremely Low Frequency Electromagnetic (ELF-EM) Waves at Resonance Frequency.
MedLine Citation:
PMID:  24766529     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: Typhoid is a serious disease difficult to be treated with conventional drugs. The aim of the present work was to demonstrate a new method for the control of Salmonella.typhi growth, through the interference with the bioelectric signals generated from the microbe during cell division by extremely low frequency electromagnetic waves (ELF-EMW- ELF-EM) at resonance frequency.
METHODS AND RESULTS: Isolated S. typhi was subjected to square amplitude modulated waves (QAMW) with different modulation frequencies from two generators with constant carrier frequency of 10 MHz, amplitude of 10 Vpp, modulating depth + 2Vpp and constant field strength of 200 V/m at 37 °C. Both the control and exposed samples were incubated at the same conditions during the experiment. The results showed that there was highly significant inhibition effect for S.typhi exposed to 0.8 Hz QAMW for a single exposure for 75 min. Dielectric relaxation, TEM and DNA results indicated highly significant changes in the molecular structure of the DNA and cellular membrane resulting from the exposure to the inhibiting EM waves.
CONCLUSIONS: It was concluded that finding out the inhibiting resonance frequency of ELF-EM waves that deteriorates Salmonella typhi growth will be promising method for the treatment of S. typhi infection either in- vivo or in- vitro.
SIGNIFICANCE AND IMPACT OF STUDY: This new non-invasive technique for treatment of bacterial infections is of considerable interest for the use in medical and biotechnological applications. This article is protected by copyright. All rights reserved.
Authors:
Fadel M Ali; Shaimaa A Mohamed; Ashraf M Abdelbacki; Amira H El-Sharkawy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-28
Journal Detail:
Title:  Journal of applied microbiology     Volume:  -     ISSN:  1365-2672     ISO Abbreviation:  J. Appl. Microbiol.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706280     Medline TA:  J Appl Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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