Document Detail

Inhibition of quorum sensing in Vibrio harveyi by boronic acids.
MedLine Citation:
PMID:  19519744     Owner:  NLM     Status:  MEDLINE    
Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chemicals called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. In this paper, we describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC(50) values in the low to sub-micromolar range in whole cell assays.
Nanting Ni; Gaurav Choudhary; Hanjing Peng; Minyong Li; Han-Ting Chou; Chung-Dar Lu; Eric S Gilbert; Binghe Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical biology & drug design     Volume:  74     ISSN:  1747-0285     ISO Abbreviation:  -     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-12     Completed Date:  2009-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262549     Medline TA:  Chem Biol Drug Des     Country:  England    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  IM    
Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4098, USA.
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MeSH Terms
Anti-Bacterial Agents / chemistry,  pharmacology*
Boronic Acids / chemistry,  pharmacology*
Quorum Sensing / drug effects*
Vibrio / drug effects*,  metabolism
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Boronic Acids

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