Document Detail

Inhibition of PG biosynthesis as the maintenance mechanism of pregnancy of hCG.
MedLine Citation:
PMID:  7376988     Owner:  NLM     Status:  MEDLINE    
In general, when the hCG values in the serum and urine reached their first peak, the PGF2 alpha and PGF2 alpha-MUM levels dropped. The hCG fell rapidly in inverse proportion to PGF2 alpha. During late pregnancy, hCG levels increased slightly and PGF2 alpha reached a low level again. From these observations, it can be stated that both PGF2 alpha and hCG played important physiologic roles in the maintenance of pregnancy. Normal pregnancy depends on this special antagonism. This anatagonism seems to be maintained by proper concentration of both hCG and PGF2 alpha. When this antagonism is disturbed during pregnancy as described above, the tendency toward decrease of hCG and increase of PGF2 alpha manifests and hence threatened abortion or actual abortion may result.
K Itoh; M H Kuo; K Omi; H Suzuki; K Kunimoto; Y Hata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in prostaglandin and thromboxane research     Volume:  8     ISSN:  0361-5952     ISO Abbreviation:  Adv Prostaglandin Thromboxane Res     Publication Date:  1980  
Date Detail:
Created Date:  1980-07-22     Completed Date:  1980-07-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7610366     Medline TA:  Adv Prostaglandin Thromboxane Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1395-400     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous / blood*,  urine
Abortion, Threatened / blood*,  drug therapy,  urine
Chorionic Gonadotropin / blood*,  therapeutic use,  urine
Prostaglandins / biosynthesis
Prostaglandins F / blood*,  urine
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Prostaglandins; 0/Prostaglandins F

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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