Document Detail

Inhibition of NO production increases myocardial blood flow and oxygen consumption in congestive heart failure.
MedLine Citation:
PMID:  12003838     Owner:  NLM     Status:  MEDLINE    
Coronary blood flow (CBF) and myocardial oxygen consumption (MVO(2)) are reduced in dogs with pacing-induced congestive heart failure (CHF), which suggests that energy metabolism is downregulated. Because nitric oxide (NO) can inhibit mitochondrial respiration, we examined the effects of NO inhibition on CBF and MVO(2) in dogs with CHF. CBF and MVO(2) were measured at rest and during treadmill exercise in 10 dogs with CHF produced by rapid ventricular pacing before and after inhibition of NO production with N(G)-nitro-L-arginine (L-NNA, 10 mg/kg iv). The development of CHF was accompanied by decreases in aortic and left ventricular (LV) systolic pressure and an increase in LV end-diastolic pressure (25 +/- 2 mmHg). L-NNA increased MVO(2) at rest (from 3.07 +/- 0.61 to 4.15 +/- 0.80 ml/min) and during exercise; this was accompanied by an increase in CBF at rest (from 31 +/- 2 to 40 +/- 4 ml/min) and during exercise (both P < 0.05). Although L-NNA significantly increased LV systolic pressure, similar increases in pressure produced by phenylephrine did not increase MVO(2). The findings suggest that NO exerts tonic inhibition on respiration in the failing heart.
Jay H Traverse; Yingjie Chen; Mingxiao Hou; Robert J Bache
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  282     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-10     Completed Date:  2002-06-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H2278-83     Citation Subset:  IM    
Division of Cardiology, Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA.
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MeSH Terms
Cardiac Pacing, Artificial
Coronary Circulation*
Energy Metabolism
Enzyme Inhibitors / pharmacology
Heart Failure / etiology,  physiopathology*
Myocardium / metabolism*
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase / antagonists & inhibitors
Nitroarginine / pharmacology
Oxygen Consumption* / drug effects
Physical Exertion
Ventricular Function, Left
Ventricular Pressure / drug effects
Grant Support
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; EC Oxide Synthase

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