| Inhibition of NO production increases myocardial blood flow and oxygen consumption in congestive heart failure. | |
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MedLine Citation:
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PMID: 12003838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary blood flow (CBF) and myocardial oxygen consumption (MVO(2)) are reduced in dogs with pacing-induced congestive heart failure (CHF), which suggests that energy metabolism is downregulated. Because nitric oxide (NO) can inhibit mitochondrial respiration, we examined the effects of NO inhibition on CBF and MVO(2) in dogs with CHF. CBF and MVO(2) were measured at rest and during treadmill exercise in 10 dogs with CHF produced by rapid ventricular pacing before and after inhibition of NO production with N(G)-nitro-L-arginine (L-NNA, 10 mg/kg iv). The development of CHF was accompanied by decreases in aortic and left ventricular (LV) systolic pressure and an increase in LV end-diastolic pressure (25 +/- 2 mmHg). L-NNA increased MVO(2) at rest (from 3.07 +/- 0.61 to 4.15 +/- 0.80 ml/min) and during exercise; this was accompanied by an increase in CBF at rest (from 31 +/- 2 to 40 +/- 4 ml/min) and during exercise (both P < 0.05). Although L-NNA significantly increased LV systolic pressure, similar increases in pressure produced by phenylephrine did not increase MVO(2). The findings suggest that NO exerts tonic inhibition on respiration in the failing heart. |
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Authors:
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Jay H Traverse; Yingjie Chen; Mingxiao Hou; Robert J Bache |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 282 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-05-10 Completed Date: 2002-06-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H2278-83 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta Cardiac Pacing, Artificial Coronary Circulation* Diastole Dogs Energy Metabolism Enzyme Inhibitors / pharmacology Heart Failure / etiology, physiopathology* Myocardium / metabolism* Nitric Oxide / biosynthesis* Nitric Oxide Synthase / antagonists & inhibitors Nitroarginine / pharmacology Oxygen Consumption* / drug effects Physical Exertion Systole Ventricular Function, Left Ventricular Pressure / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-20598/HL/NHLBI NIH HHS; HL-21872/HL/NHLBI NIH HHS; HL-58067/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; EC 1.14.13.39/Nitric Oxide Synthase |
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