Document Detail


Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv.
MedLine Citation:
PMID:  11277323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Picroliv, an iridoid glycoside mixture prepared from the roots and rhizomes of Picrorhiza kurroa was found to be an effective inhibitor of hepatocarcinogenesis induced by N-Nitrosodiethylamine (NDEA) in rats. Animals administered with NDEA had large hepatic nodules and the liver weight was increased to 6.17 +/- 1.0 g/100 g.b.wt. as compared to the normal liver weight 2.84 +/- 0.08 g/100 g.b.wt. Picroliv administration (200 mg/Kg.b.wt) reduced the liver weight to 3.30 +/- 0.23 g/100 g.b.wt. Oral administration of Picroliv reduced NDEA-induced elevation of gamma-glutamyltranspeptidase (gamma-GT) in serum and liver to that of normal rats. Moreover, elevated levels of bilirubin, alkaline phosphatase (ALP), glutamatepyruvate transaminase (GPT) and serum peroxides were also found to be significantly reduced by Picroliv administration. Similar observations were noticed in glutathione (GSH) and glutathione S-transferase (GST) levels. Histopathological analysis of the Picroliv treated rat liver resembles that of a normal liver except for a few alterations such as hepatocytomegalia and karyomegalia in some focii. The results are indicative of the chemopreventive potential of Picroliv against chemically-induced liver tumours.
Authors:
N V Rajeshkumar; R Kuttan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of experimental & clinical cancer research : CR     Volume:  19     ISSN:  0392-9078     ISO Abbreviation:  J. Exp. Clin. Cancer Res.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-03-29     Completed Date:  2001-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8308647     Medline TA:  J Exp Clin Cancer Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  459-65     Citation Subset:  IM    
Affiliation:
Amala Cancer Research Centre, Thrissur, Kerala, India.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Anticarcinogenic Agents / administration & dosage,  therapeutic use*
Antioxidants / pharmacology
Carcinogens / toxicity
Cinnamates / administration & dosage,  therapeutic use*
Diethylnitrosamine / toxicity*
Glycosides / administration & dosage,  therapeutic use*
Hydroxyl Radical / metabolism
Lipid Peroxidation / drug effects
Liver / drug effects*,  metabolism,  pathology
Liver Neoplasms, Experimental / chemically induced*,  pathology,  prevention & control*
Male
Organ Size / drug effects
Plant Extracts / therapeutic use
Rats
Rats, Wistar
Superoxides / metabolism
Vanillic Acid / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Antioxidants; 0/Carcinogens; 0/Cinnamates; 0/Glycosides; 0/Plant Extracts; 11062-77-4/Superoxides; 121-34-6/Vanillic Acid; 12708-05-3/kutkin; 3352-57-6/Hydroxyl Radical; 55-18-5/Diethylnitrosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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