| Inhibition of maternal behaviour by central infusion of corticotrophin-releasing hormone in marmoset monkeys. | |
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MedLine Citation:
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PMID: 21554432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stress can inhibit maternal behaviour and increase rates of child abuse in humans and other animals; however, the neuroendocrine mechanisms are not known. To determine whether corticotrophin-releasing hormone (CRH) plays a role in stress-induced disruption of maternal behaviour in primates, we characterised the effects of acute i.c.v. infusions of CRH on maternal and abusive behaviour in common marmoset monkeys (Callithrix jacchus). Nulliparous females were implanted with indwelling i.c.v. guide cannulae before conception. Between 18 and 58 days after the birth of her first infants, each female underwent a series of i.c.v. infusions of human CRH (0, 2, 8 and 25 μg) in 8 μl of artificial cerebrospinal fluid. In the 70 min after infusion, marmosets were tested with one of their infants, first in their home cage and, subsequently, in an unfamiliar cage in which the infant was confined in a transparent box on the cage floor. In the home cage, the highest dose of CRH significantly reduced the amount of time that mothers spent carrying their infants, as compared to vehicle alone, although it did not reliably affect aggression toward the infant or other behaviours. In the confined-infant test, the highest dose of CRH significantly reduced the amount of time that mothers spent on the cage floor, increased mothers' vocalisation rates, and tended to reduce their activity levels and time spent in proximity to their infant. Twenty-five micrograms of CRH also elicited significant elevations in plasma adrenocorticotrophic hormone and cortisol concentrations compared to vehicle. These results indicate that i.c.v.-administered CRH reduces maternal behaviour in marmoset mothers, in both familiar and unfamiliar environments, but does not increase infant abuse. |
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Authors:
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W Saltzman; C A Boettcher; J L Post; D H Abbott |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of neuroendocrinology Volume: 23 ISSN: 1365-2826 ISO Abbreviation: J. Neuroendocrinol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-18 Completed Date: 2012-02-10 Revised Date: 2013-05-24 |
Medline Journal Info:
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Nlm Unique ID: 8913461 Medline TA: J Neuroendocrinol Country: England |
Other Details:
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Languages: eng Pagination: 1139-48 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Journal of Neuroendocrinology © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Biology, University of California, Riverside, CA 92521, USA. saltzman@ucr.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood Animals Behavior, Animal* Callithrix / physiology* Corticotropin-Releasing Hormone / administration & dosage* Female Hydrocortisone / blood Injections, Intraventricular Mothers* Progesterone / blood Radioimmunoassay |
| Grant Support | |
ID/Acronym/Agency:
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MH075973/MH/NIMH NIH HHS; R21 MH075973-01A1/MH/NIMH NIH HHS; R21 MH075973-02/MH/NIMH NIH HHS; RR020141-01/RR/NCRR NIH HHS; RR15459-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 57-83-0/Progesterone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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