Document Detail


Inhibition of maternal behaviour by central infusion of corticotrophin-releasing hormone in marmoset monkeys.
MedLine Citation:
PMID:  21554432     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stress can inhibit maternal behaviour and increase rates of child abuse in humans and other animals; however, the neuroendocrine mechanisms are not known. To determine whether corticotrophin-releasing hormone (CRH) plays a role in stress-induced disruption of maternal behaviour in primates, we characterised the effects of acute i.c.v. infusions of CRH on maternal and abusive behaviour in common marmoset monkeys (Callithrix jacchus). Nulliparous females were implanted with indwelling i.c.v. guide cannulae before conception. Between 18 and 58 days after the birth of her first infants, each female underwent a series of i.c.v. infusions of human CRH (0, 2, 8 and 25 μg) in 8 μl of artificial cerebrospinal fluid. In the 70 min after infusion, marmosets were tested with one of their infants, first in their home cage and, subsequently, in an unfamiliar cage in which the infant was confined in a transparent box on the cage floor. In the home cage, the highest dose of CRH significantly reduced the amount of time that mothers spent carrying their infants, as compared to vehicle alone, although it did not reliably affect aggression toward the infant or other behaviours. In the confined-infant test, the highest dose of CRH significantly reduced the amount of time that mothers spent on the cage floor, increased mothers' vocalisation rates, and tended to reduce their activity levels and time spent in proximity to their infant. Twenty-five micrograms of CRH also elicited significant elevations in plasma adrenocorticotrophic hormone and cortisol concentrations compared to vehicle. These results indicate that i.c.v.-administered CRH reduces maternal behaviour in marmoset mothers, in both familiar and unfamiliar environments, but does not increase infant abuse.
Authors:
W Saltzman; C A Boettcher; J L Post; D H Abbott
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  23     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-18     Completed Date:  2012-02-10     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1139-48     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Journal of Neuroendocrinology © 2011 Blackwell Publishing Ltd.
Affiliation:
Department of Biology, University of California, Riverside, CA 92521, USA. saltzman@ucr.edu
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Animals
Behavior, Animal*
Callithrix / physiology*
Corticotropin-Releasing Hormone / administration & dosage*
Female
Hydrocortisone / blood
Injections, Intraventricular
Mothers*
Progesterone / blood
Radioimmunoassay
Grant Support
ID/Acronym/Agency:
MH075973/MH/NIMH NIH HHS; R21 MH075973-01A1/MH/NIMH NIH HHS; R21 MH075973-02/MH/NIMH NIH HHS; RR020141-01/RR/NCRR NIH HHS; RR15459-01/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone; 57-83-0/Progesterone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone
Comments/Corrections

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