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Inhibition of Immobilization Stress-induced Anorexia, Behavioral Deficits and Plasma Corticosterone Secretion by Injected Leptin in Rats.
MedLine Citation:
PMID:  23035922     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Leptin, originally identified as an anti-obesity hormone, also has an important role in the regulation of mood and emotion. The present study was designed to monitor effects of injected leptin on immobilization stress-induced anorexia, behavioral deficits and plasma corticosterone secretion in rats. Exposure to 2h immobilization stress decreased food intake and body weight in saline injected animals. Animals exposed to open field, elevated plus maze and light dark transition tests the day following immobilization exhibited anxiety-like behavior. Leptin injected at doses of 0.1 and 0.5 mg/kg also decreased food intake and body weight in unstressed animals and elicited anxiolytic effects at dose of 0.5 mg/kg, monitored on the following day. Immobilization -induced decreases in food intake, body weight, as well as stress-induced behavioral deficits in the open field, elevated plus maze and light dark transition test were reversed by exogenous leptin in a dose dependent (0.1-0.5mg/kg) manner. Acute exposure to 2h immobilization produced a four-fold rise in plasma levels of corticosterone. Animals injected with leptin at a dose of 0.1mg/kg, but not at dose of 0.5 mg/kg exhibited a marginal increase in plasma corticosterone. Immobilization-induced increases of plasma corticosterone were reversed by leptin injected at doses of 0.1mg/kg or 0.5 mg/kg. The data suggest that exogenous leptin can reduce stress perception, resulting in an inhibition of stress effects on the activity of hypothalamic-pituitary-adrenal (HPA) axis and behavior. The reported pharmacological effects of leptin represent an innovative approach for the treatment of stress-related disorders.
Authors:
Zeba Haque; Nazia Akbar; Farzana Yasmeen; Muhammad A Haleem; Darakhshan J Haleem
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  -     ISSN:  1607-8888     ISO Abbreviation:  Stress     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi , Karachi 75270 , Pakistan.
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