Document Detail


Inhibition of HIV fusion with multivalent gold nanoparticles.
MedLine Citation:
PMID:  18473457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics.
Authors:
Mary-Catherine Bowman; T Eric Ballard; Christopher J Ackerson; Daniel L Feldheim; David M Margolis; Christian Melander
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-05-13
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  130     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-28     Completed Date:  2008-08-07     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6896-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amides / chemistry,  pharmacology*
Gold / chemistry*,  pharmacology*
HIV Fusion Inhibitors / chemistry,  pharmacology*
HIV Infections / drug therapy
HIV-1 / physiology
Metal Nanoparticles / chemistry*,  therapeutic use
Quaternary Ammonium Compounds / chemistry,  pharmacology*
Grant Support
ID/Acronym/Agency:
AI045297/AI/NIAID NIH HHS; AI50410/AI/NIAID NIH HHS; EY017568/EY/NEI NIH HHS; P30 AI050410/AI/NIAID NIH HHS; P30 AI050410-08/AI/NIAID NIH HHS; R01 AI045297/AI/NIAID NIH HHS; R01 AI045297-10/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Amides; 0/HIV Fusion Inhibitors; 0/Quaternary Ammonium Compounds; 229005-80-5/TAK 779; 7440-57-5/Gold
Comments/Corrections

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