Document Detail


Inhibition of HIV-1 replication by an antiviral xanthate compound in vitro.
MedLine Citation:
PMID:  3365357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antiviral xanthate compound tricyclodecan-9-yl-xanthogenate (code name D609) is capable of inhibiting DNA and RNA viruses in vitro. It can also inhibit the shedding of infectious HIV into the tissue culture medium from chronically infected lymphoma cells (KE37-III) as shown by infectivity assays and Western blots of the supernatant. HIV-specific proteins, however, were accumulated intracellularly. The initiation of a de novo HIV replication after infection of permissive KE37-1 cells was completely inhibited at concentrations of D609 which still permitted mitotic divisions of the cells. Furthermore, the selective antiviral activity of the xanthate compound was evidenced by the absence of HIV replicative intermediate DNA. The expression of cellular genes, such as c-myc, remained unimpaired within these cells.
Authors:
W Mellert; E Amtmann; V Erfle; G Sauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  4     ISSN:  0889-2229     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-06-23     Completed Date:  1988-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-81     Citation Subset:  IM; X    
Affiliation:
Abt. für Molekulare Zellpathologie, Gesellschaft für Strahlen und Umweltforschung (GSF), Neuherberg/München, West Germany.
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / pharmacology
Bridged Compounds / pharmacology*
Cell Division / drug effects
Cell Line
HIV / drug effects*,  physiology
Humans
Proto-Oncogenes / drug effects
Thiones / pharmacology*
Virus Replication / drug effects*
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Bridged Compounds; 0/Thiones; 83373-60-8/tricyclodecane-9-yl-xanthogenate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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