| Inhibition of HIV-1 replication by an antiviral xanthate compound in vitro. | |
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MedLine Citation:
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PMID: 3365357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiviral xanthate compound tricyclodecan-9-yl-xanthogenate (code name D609) is capable of inhibiting DNA and RNA viruses in vitro. It can also inhibit the shedding of infectious HIV into the tissue culture medium from chronically infected lymphoma cells (KE37-III) as shown by infectivity assays and Western blots of the supernatant. HIV-specific proteins, however, were accumulated intracellularly. The initiation of a de novo HIV replication after infection of permissive KE37-1 cells was completely inhibited at concentrations of D609 which still permitted mitotic divisions of the cells. Furthermore, the selective antiviral activity of the xanthate compound was evidenced by the absence of HIV replicative intermediate DNA. The expression of cellular genes, such as c-myc, remained unimpaired within these cells. |
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Authors:
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W Mellert; E Amtmann; V Erfle; G Sauer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 4 ISSN: 0889-2229 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-06-23 Completed Date: 1988-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 71-81 Citation Subset: IM; X |
Affiliation:
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Abt. für Molekulare Zellpathologie, Gesellschaft für Strahlen und Umweltforschung (GSF), Neuherberg/München, West Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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pharmacology Bridged Compounds / pharmacology* Cell Division / drug effects Cell Line HIV / drug effects*, physiology Humans Proto-Oncogenes / drug effects Thiones / pharmacology* Virus Replication / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Bridged Compounds; 0/Thiones; 83373-60-8/tricyclodecane-9-yl-xanthogenate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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