Document Detail

Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions.
MedLine Citation:
PMID:  18477469     Owner:  NLM     Status:  MEDLINE    
In the present study, we have investigated the effects of glycogen synthase kinase-3 (GSK-3) inhibition on infarct volume and neurobehavioral functions in a focal cerebral ischemia model. To achieve our goals, GSK-3 inhibitor II or VIII was injected at several time points and in varing dosages. GSK-3 inhibitor VIII was more effective than inhibitor II, and infarct volume and water content in the VIII group were significantly decreased 24h after the onset of ischemic stroke, as compared with the control group. These protective effects were associated with reductions of TUNEL-positive cells, neutrophil infiltration, glucose levels after ischemia, and GSK-3 enzyme activity. In addition, expressions of death and inflammation-related signals decreased and those of survival-related signals increased. Lastly, neurobehavioral functions were restored to a greater extent in the VIII group than in the control group. Together, these results suggest that GSK-3 inhibition reduces infarct volume and restores neurobehavioral functions.
Seong-Ho Koh; A Rum Yoo; Dae-Il Chang; Se J Hwang; Seung H Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-12
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  371     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-06-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  894-9     Citation Subset:  IM    
Department of Neurology, College of Medicine, Hanyang University, #17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea.
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MeSH Terms
Behavior, Animal / drug effects
Blood Glucose / analysis
Brain Edema / enzymology,  etiology,  pathology*
Calcium-Binding Proteins / analysis
Caspase 3 / analysis
Cerebral Infarction / complications,  enzymology,  pathology*
Cyclooxygenase 2 / analysis
Disease Models, Animal
Glial Fibrillary Acidic Protein / analysis
Glycogen Synthase Kinase 3 / analysis,  antagonists & inhibitors*
Oxadiazoles / administration & dosage
Poly(ADP-ribose) Polymerases / analysis
Protein Kinase Inhibitors / administration & dosage*
Pyridines / administration & dosage
Rats, Sprague-Dawley
Thiazoles / administration & dosage
Urea / administration & dosage,  analogs & derivatives
Reg. No./Substance:
0/2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole; 0/Aif1 protein, rat; 0/Blood Glucose; 0/Calcium-Binding Proteins; 0/Glial Fibrillary Acidic Protein; 0/N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea; 0/Oxadiazoles; 0/Protein Kinase Inhibitors; 0/Pyridines; 0/Thiazoles; 57-13-6/Urea; EC 2; EC protein, rat; EC Polymerases; EC Synthase Kinase 3; EC 3.4.22.-/Caspase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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