Document Detail

Inhibition of Fusarium graminearum growth and development by farnesol.
MedLine Citation:
PMID:  18201191     Owner:  NLM     Status:  MEDLINE    
The isoprenoid farnesol was previously shown to induce morphological features characteristic of apoptosis in the filamentous fungus Aspergillus nidulans. This study demonstrates that under similar liquid media growth conditions, farnesol also triggers apoptosis in the plant pathogenic fungus Fusarium graminearum. However, unlike A. nidulans, F. graminearum spores treated with farnesol exhibited altered germination patterns and most (>60%) lysed upon prolonged exposure. Given the economic importance of F. graminearum as a pathogen of small grains, this study proposes that farnesol may have potential value as an antifungal compound.
Camile P Semighini; Nicholas Murray; Steven D Harris
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-14
Journal Detail:
Title:  FEMS microbiology letters     Volume:  279     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-25     Completed Date:  2008-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Plant Science Initiative and Department of Plant Pathology, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
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MeSH Terms
Antifungal Agents / pharmacology*
Apoptosis / drug effects
Farnesol / pharmacology*
Fusarium / drug effects*,  growth & development*
Spores, Fungal / drug effects
Reg. No./Substance:
0/Antifungal Agents; 4602-84-0/Farnesol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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