Document Detail


Inhibition of Friend cell erythrodifferentiation by modification of membrane phospholipid composition by choline analogues.
MedLine Citation:
PMID:  3855361     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dimethylsulfoxide-stimulated Friend leukemia cell erythrodifferentiation was inhibited by choline analogues such as N-monomethylethanolamine and N,N-dimethylethanolamine. Phosphatidyl-N-monomethylethanolamine and phosphatidyl-N,N-dimethylethanolamine were then accumulated in the cell membranes. N-Monomethylethanolamine also inhibited Friend leukemia cell erythrodifferentiation stimulated by hexamethylene bisacetamide and N-methylacetamide, but did not inhibit differentiation induced by sodium butyrate. This inhibitory effect of N-monomethylethanolamine was partially abrogated by spermine.
Authors:
S Kaiho; K Mizuno
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  838     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-03-20     Completed Date:  1985-03-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  175-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / drug effects
Cell Line
Choline / analogs & derivatives*
Deanol / pharmacology
Dimethyl Sulfoxide / pharmacology
Erythrocyte Membrane / drug effects,  metabolism*
Ethanolamines / pharmacology
Friend murine leukemia virus
Leukemia, Erythroblastic, Acute / metabolism,  pathology*
Phosphatidylethanolamines / blood
Phospholipids / blood*
Chemical
Reg. No./Substance:
0/Ethanolamines; 0/Phosphatidylethanolamines; 0/Phospholipids; 0/phosphatidyl-N-monomethylaminoethanol; 0/phosphatidyldimethylethanolamine; 108-01-0/Deanol; 109-83-1/N-methylaminoethanol; 62-49-7/Choline; 67-68-5/Dimethyl Sulfoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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