| Inhibition of the Experimental Induction of Benign Prostatic Hyperplasia: A Possible Role for Fluted Pumpkin (Telfairia occidentalis Hook f.) Seeds. | |
| | |
MedLine Citation:
|
PMID: 21709398 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: Pumpkins are thought to be useful in the management of benign prostatic hyperplasia (BPH). The ability of a 15% Telfairia occidentalis seeds incorporated diet to inhibit hormonal induction of BPH in rats was studied. Materials and Methods: Twenty male Wistar rats were divided into 4 equal groups - one test group and three control groups. The test group was placed on the test diet and was given subcutaneous injections of dihydrotestosterone (DHT) and estradiol valerate (ratio 10:1) every other day for 28 days. One control group, 'no test diet' (ND) group, received the hormones, but was placed on a normal diet. The other two control groups, 'no hormone' (NH) and 'no hormone/test diet' (NHD), received subcutaneous olive oil (vehicle) for the same duration and were placed on the test and normal diets, respectively. Markers of BPH and hormone profile were determined using standard methods. Results: The mean relative prostate weight (×10(3)) was reduced in the test group (3.6 ± 0.2) relative to the ND group (4.0 ± 0.4). The protein content (mg/tissue) of the rats' prostates decreased significantly (p < 0.05) from 68.3 ± 2.7 in the ND group to 43.4 ± 3.9 in the test group. Serum prostatic acid phosphatase levels (U/l) decreased significantly (p < 0.05) from 4.8 ± 0.4 in the ND group to 4.0 ± 0.9 in the test group. Histological findings corroborate these data. The testosterone:estradiol ratio (×10(3)) was significantly (p < 0.05) increased from 7.1 ± 0.1 in the ND group to 8.4 ± 0.4 in the test group. Conclusion: The test diet inhibited the induction of BPH in rats and may act by increasing the testosterone:estradiol ratio. |
| | |
Authors:
|
Chukwunonso E C C Ejike; Lawrence U S Ezeanyika |
Related Documents
:
|
16699308 - Restriction of dietary iodine does not ameliorate the early effect of anti-thyroid drug... 16857878 - Feeding and osmoregulation: dual function of the marine teleost intestine. 19435218 - Prophylactic supplementation of caprylic acid in feed reduces salmonella enteritidis co... 3198528 - The influence of high planes of nutrition on skeletal growth and development of weanlin... 1338318 - Strategies to minimize weight gain after smoking cessation: psychological and pharmacol... 12771368 - Evaluation of the effects of the dietary intake of proteins and amino acids by dna micr... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-28 |
Journal Detail:
|
Title: Urologia internationalis Volume: - ISSN: 1423-0399 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417373 Medline TA: Urol Int Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
|
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Nigeria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Morphometric Differences between the Medial and Lateral Meniscus in Healthy Men - A Three-Dimensiona...
Next Document: Simultaneous Correction of Anterior and Apical Vaginal Prolapse with the Modified Placement of the T...