Document Detail

Inhibition of the ERK pathway prevents HIVgp120-induced REM sleep increase.
MedLine Citation:
PMID:  11532249     Owner:  NLM     Status:  MEDLINE    
Approximately 35% of HIV-infected subjects, both children and adults, exhibit alterations in the sleep-waking cycle. HIV surface glycoprotein gp120 has been postulated to contribute to this abnormality. For example, it has been reported that HIVgp120 modifies sleep in freely-moving rats and that it also activates the ERK pathway in brain slices. The goal of this work was to determine if sleep changes induced by HIVgp120 in normal rats are mediated by the MAPK pathway. Our results show that a single intraventricular administration of HIVgp120 selectively increases REMS and that such an increase can be prevented by U0126, an inhibitor of ERK activating enzyme, MEK. In contrast, SB202190, a MAPK-p38 inhibitor, had no effect on HIVgp120-induced increase in REMS. These results suggest that HIVgp120 increases REMS in the rat by specifically affecting the ERK signal transduction pathway.
O Díaz-Ruiz; L Navarro; M Méndez-Díaz; O Galicia; J H Elder; P P Sanna; R Drucker-Colín; O Prospéro-García
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  913     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-04     Completed Date:  2001-12-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  78-81     Citation Subset:  IM    
Grupo de Neurociencias, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Apartado postal 70-250, 04510 México D.F., Mexico.
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MeSH Terms
AIDS Dementia Complex / enzymology*,  physiopathology,  virology
Brain / drug effects,  enzymology*,  virology
Butadienes / pharmacology
Drug Interactions / physiology
Enzyme Inhibitors / pharmacology
HIV Envelope Protein gp120 / metabolism,  pharmacology*
Imidazoles / pharmacology
MAP Kinase Signaling System / drug effects,  physiology*
Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors,  metabolism
Mitogen-Activated Protein Kinases / antagonists & inhibitors,  metabolism*
Nitriles / pharmacology
Pyridines / pharmacology
REM Sleep Parasomnias / chemically induced,  enzymology*,  virology
Rats, Wistar
Sleep, REM / drug effects,  physiology*
Wakefulness / drug effects,  physiology
p38 Mitogen-Activated Protein Kinases
Reg. No./Substance:
0/4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; 0/Butadienes; 0/Enzyme Inhibitors; 0/HIV Envelope Protein gp120; 0/Imidazoles; 0/Nitriles; 0/Pyridines; 0/U 0126; EC Protein Kinases; EC Mitogen-Activated Protein Kinases; EC Protein Kinase Kinases

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