| Inhibition of the ERK pathway prevents HIVgp120-induced REM sleep increase. | |
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MedLine Citation:
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PMID: 11532249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Approximately 35% of HIV-infected subjects, both children and adults, exhibit alterations in the sleep-waking cycle. HIV surface glycoprotein gp120 has been postulated to contribute to this abnormality. For example, it has been reported that HIVgp120 modifies sleep in freely-moving rats and that it also activates the ERK pathway in brain slices. The goal of this work was to determine if sleep changes induced by HIVgp120 in normal rats are mediated by the MAPK pathway. Our results show that a single intraventricular administration of HIVgp120 selectively increases REMS and that such an increase can be prevented by U0126, an inhibitor of ERK activating enzyme, MEK. In contrast, SB202190, a MAPK-p38 inhibitor, had no effect on HIVgp120-induced increase in REMS. These results suggest that HIVgp120 increases REMS in the rat by specifically affecting the ERK signal transduction pathway. |
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Authors:
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O Díaz-Ruiz; L Navarro; M Méndez-Díaz; O Galicia; J H Elder; P P Sanna; R Drucker-Colín; O Prospéro-García |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 913 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-04 Completed Date: 2001-12-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 78-81 Citation Subset: IM |
Affiliation:
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Grupo de Neurociencias, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Apartado postal 70-250, 04510 México D.F., Mexico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS Dementia Complex
/
enzymology*,
physiopathology,
virology Animals Brain / drug effects, enzymology*, virology Butadienes / pharmacology Drug Interactions / physiology Enzyme Inhibitors / pharmacology HIV Envelope Protein gp120 / metabolism, pharmacology* Imidazoles / pharmacology MAP Kinase Signaling System / drug effects, physiology* Male Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors, metabolism Mitogen-Activated Protein Kinases / antagonists & inhibitors, metabolism* Nitriles / pharmacology Pyridines / pharmacology REM Sleep Parasomnias / chemically induced, enzymology*, virology Rats Rats, Wistar Sleep, REM / drug effects, physiology* Wakefulness / drug effects, physiology p38 Mitogen-Activated Protein Kinases |
| Chemical | |
Reg. No./Substance:
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0/4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; 0/Butadienes; 0/Enzyme Inhibitors; 0/HIV Envelope Protein gp120; 0/Imidazoles; 0/Nitriles; 0/Pyridines; 0/U 0126; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases; EC 2.7.12.2/Mitogen-Activated Protein Kinase Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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